%0 Journal Article %1 becskei2005lownumber %A Becskei, A. %A Kaufmann, B. B. %A van Oudenaarden, A. %D 2005 %J Nat Genet %K bursting stochastic_transcription %N 9 %P 937-944 %R 10.1038/ng1616 %T Contributions of low molecule number and chromosomal positioning to stochastic gene expression %U http://www.ncbi.nlm.nih.gov/pubmed/16086016 %V 37 %X The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low-abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events of gene activation. The frequency of these events and the correlation between stochastic expressions of genes in a single cell depend on the positioning of the genes along the chromosomes. Transcriptional regulators produced by such random expression propagate noise to their target genes.

@article{becskei2005lownumber, abstract = {The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low-abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events of gene activation. The frequency of these events and the correlation between stochastic expressions of genes in a single cell depend on the positioning of the genes along the chromosomes. Transcriptional regulators produced by such random expression propagate noise to their target genes.}, added-at = {2010-07-22T04:46:34.000+0200}, author = {Becskei, A. and Kaufmann, B. B. and {van Oudenaarden}, A.}, biburl = {https://www.bibsonomy.org/bibtex/202c68ed6f25d1bc47094660838a9d0c1/peter.ralph}, description = {Contributions of low molecule number and chromosom... [Nat Genet. 2005] - PubMed result}, doi = {10.1038/ng1616}, interhash = {eceb1260336d55a2817f964ce7cdbb08}, intrahash = {02c68ed6f25d1bc47094660838a9d0c1}, journal = {Nat Genet}, keywords = {bursting stochastic_transcription}, month = sep, number = 9, pages = {937-944}, pmid = {16086016}, timestamp = {2010-07-22T04:46:34.000+0200}, title = {Contributions of low molecule number and chromosomal positioning to stochastic gene expression}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16086016}, volume = 37, year = 2005 }