%0 Book Section %1 statphys23_1064 %A Taflia, T.H. %A Holcman, D.D. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K boundary brownian first mean mixed motion passage problem statphys23 synaptic time topic-10 value weight %T Dwell time of a Brownian interacting molecule in a cellular microdomain %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=1064 %X The mechanism that regulates the number and the type of receptors at a synapse control the synaptic weight. Any fluctuations of their number results in a variation of the synaptic weight and affects the reliability of the synaptic transmission. Moreover, certain experimental protocols have lead to a Long Term Potentiation of a synapse, a mechanism which is associated with a change of the number and the type of certain receptors . The regulation of synaptic plasticity is a fundamental process underlying learning and memory. Recently, single molecule tracking has revealed that the number of postsynaptic receptors, which participate to the synaptic transmission, is not fixed but it changes due to constant traffick of receptors on the surface of neurons. Receptors move in and out from synaptic regions and following these observations, many questions have been raised: in particular, what determines the time spent by a receptor inside a synapse? How receptors can be stabilized inside a synapse? How long they stay inside synaptic microdomains? Such questions are partially answered in the present paper. In particular, our computation of the Dwell time of a receptor inside a specific microdomain,called post synaptic domain (PSD). In the present article, we propose to estimate the mean time spent by a Brownian molecule inside a microdomain which contains a small hole on the boundary and agonist molecules located inside. We found that the mean time depends on several parameters such as the backward binding rate (with the agonist molecules), the mean escape time from the microdomain and the mean time a molecule reaches the binding sites (forward binding rate). In addition, we estimate the mean and the variance of the number of bounds made by a molecule before it exits. In particular, we apply the present results to obtain an estimate of the mean time spent (Dwell time) by a Brownian receptor inside a synaptic domain, when it moves freely by lateral diffusion on the surface of a neuron and interacts locally with scaffolding molecules.

@incollection{statphys23_1064, abstract = {The mechanism that regulates the number and the type of receptors at a synapse control the synaptic weight. Any fluctuations of their number results in a variation of the synaptic weight and affects the reliability of the synaptic transmission. Moreover, certain experimental protocols have lead to a Long Term Potentiation of a synapse, a mechanism which is associated with a change of the number and the type of certain receptors . The regulation of synaptic plasticity is a fundamental process underlying learning and memory. Recently, single molecule tracking has revealed that the number of postsynaptic receptors, which participate to the synaptic transmission, is not fixed but it changes due to constant traffick of receptors on the surface of neurons. Receptors move in and out from synaptic regions and following these observations, many questions have been raised: in particular, what determines the time spent by a receptor inside a synapse? How receptors can be stabilized inside a synapse? How long they stay inside synaptic microdomains? Such questions are partially answered in the present paper. In particular, our computation of the Dwell time of a receptor inside a specific microdomain,called post synaptic domain (PSD). In the present article, we propose to estimate the mean time spent by a Brownian molecule inside a microdomain which contains a small hole on the boundary and agonist molecules located inside. We found that the mean time depends on several parameters such as the backward binding rate (with the agonist molecules), the mean escape time from the microdomain and the mean time a molecule reaches the binding sites (forward binding rate). In addition, we estimate the mean and the variance of the number of bounds made by a molecule before it exits. In particular, we apply the present results to obtain an estimate of the mean time spent (Dwell time) by a Brownian receptor inside a synaptic domain, when it moves freely by lateral diffusion on the surface of a neuron and interacts locally with scaffolding molecules.}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Taflia, T.H. and Holcman, D.D.}, biburl = {https://www.bibsonomy.org/bibtex/2334ea6c67262b6505773197e343a6a93/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {ef65eb3aa216297fc49e5af48aa6fa48}, intrahash = {334ea6c67262b6505773197e343a6a93}, keywords = {boundary brownian first mean mixed motion passage problem statphys23 synaptic time topic-10 value weight}, month = {9-13 July}, timestamp = {2007-06-20T10:16:38.000+0200}, title = {Dwell time of a Brownian interacting molecule in a cellular microdomain}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=1064}, year = 2007 }