%0 Journal Article %1 Phillips2007 %A Phillips, John P %A Sullivan, Katherine J %A Burtner, Patricia A %A Caprihan, Arvind %A Provost, Beth %A Bernitsky-Beddingfield, Ann %D 2007 %J Dev Med Child Neurol %K Adolescent; Ankle; Body Weight; Brain; Cerebral Palsy; Child; Feasibility Studies; Female; Functional Laterality; Gait; Humans; Magnetic Resonance Imaging; Male; Neuronal Plasticity; Physical Therapy Modalities; Pilot Projects; Teaching; Time Factors; Treatment Outcome %N 1 %P 39--44 %R 10.1111/j.1469-8749.2007.0102a.x %T Ankle dorsiflexion fMRI in children with cerebral palsy undergoing intensive body-weight-supported treadmill training: a pilot study. %U http://dx.doi.org/10.1111/j.1469-8749.2007.0102a.x %V 49 %X This pilot study investigated the feasibility of using functional magnetic resonance imaging (fMRI) as a physiological marker of brain plasticity before and after an intensive body-weight-supported treadmill training (BWSTT) program in children with cerebral palsy (CP). Six ambulatory children (four males, two females; mean age 10y 6mo, age range 6-14y) with spastic CP (four hemiplegia, two asymmetric diplegia, all Gross Motor Function Classification System Level I) received BWSTT twice daily for 2 weeks. All children tolerated therapy; only one therapy session was aborted due to fatigue. With training, over ground mean walking speed increased from 1.47 to 1.66m/s (p=0.035). There was no change in distance walked for 6 minutes (pre-: 451m; post-: 458m;p 0.851). In three children, reliable fMRIs were taken of cortical activation pre- and post-intervention. Post-intervention increases in cortical activation during ankle dorsiflexion were observed in all three children. This study demonstrates that children with CP between 6 and 14 years of age can tolerate intensive locomotor training and, with appropriate modifications, can complete an fMRI series. This study supports further studies designed to investigate training-dependent plasticity in children with CP.

@article{Phillips2007, abstract = {This pilot study investigated the feasibility of using functional magnetic resonance imaging (fMRI) as a physiological marker of brain plasticity before and after an intensive body-weight-supported treadmill training (BWSTT) program in children with cerebral palsy (CP). Six ambulatory children (four males, two females; mean age 10y 6mo, age range 6-14y) with spastic CP (four hemiplegia, two asymmetric diplegia, all Gross Motor Function Classification System Level I) received BWSTT twice daily for 2 weeks. All children tolerated therapy; only one therapy session was aborted due to fatigue. With training, over ground mean walking speed increased from 1.47 to 1.66m/s (p=0.035). There was no change in distance walked for 6 minutes (pre-: 451m; post-: 458m;p 0.851). In three children, reliable fMRIs were taken of cortical activation pre- and post-intervention. Post-intervention increases in cortical activation during ankle dorsiflexion were observed in all three children. This study demonstrates that children with CP between 6 and 14 years of age can tolerate intensive locomotor training and, with appropriate modifications, can complete an fMRI series. This study supports further studies designed to investigate training-dependent plasticity in children with CP.}, added-at = {2014-07-19T21:01:42.000+0200}, author = {Phillips, John P and Sullivan, Katherine J and Burtner, Patricia A and Caprihan, Arvind and Provost, Beth and Bernitsky-Beddingfield, Ann}, biburl = {https://www.bibsonomy.org/bibtex/286a2b255084d701d0e9d806f0d1fe2c8/ar0berts}, doi = {10.1111/j.1469-8749.2007.0102a.x}, groups = {public}, interhash = {f2cb9a89b7a47c93ff817d262a73be6b}, intrahash = {86a2b255084d701d0e9d806f0d1fe2c8}, journal = {Dev Med Child Neurol}, keywords = {Adolescent; Ankle; Body Weight; Brain; Cerebral Palsy; Child; Feasibility Studies; Female; Functional Laterality; Gait; Humans; Magnetic Resonance Imaging; Male; Neuronal Plasticity; Physical Therapy Modalities; Pilot Projects; Teaching; Time Factors; Treatment Outcome}, month = Jan, number = 1, pages = {39--44}, pii = {DMCN0102a}, pmid = {17209975}, timestamp = {2014-07-19T21:01:42.000+0200}, title = {Ankle dorsiflexion fMRI in children with cerebral palsy undergoing intensive body-weight-supported treadmill training: a pilot study.}, url = {http://dx.doi.org/10.1111/j.1469-8749.2007.0102a.x}, username = {ar0berts}, volume = 49, year = 2007 }