%0 Generic %1 borck2010linkage %A Borck, Cornelia %D 2010 %K linkage selective_sweep soft_sweeps %T The Effect of Recurrent Mutation on the Linkage Disequilibrium under a Selective Sweep %U http://arxiv.org/abs/1009.3150 %X A selective sweep describes the reduction of diversity due to strong positive selection. If the mutation rate to a selectively beneficial allele is sufficiently high, Pennings and Hermisson (2006a) have shown, that it becomes likely, that a selective sweep is caused by several individuals. Such an event is called a soft sweep and the complementary event of a single origin of the beneficial allele, the classical case, a hard sweep. We give analytical expressions for the linkage disequilibrium (LD) between two neutral loci linked to the selected locus, depending on the recurrent mutation to the beneficial allele, measured by $D$ and $\sigma_D^2$, a quantity introduced by Ohta and Kimura (1969), and conclude that the LD-pattern of a soft sweep differs substantially from that of a hard sweep due to haplotype structure. We compare our results with simulations.

@misc{borck2010linkage, abstract = { A selective sweep describes the reduction of diversity due to strong positive selection. If the mutation rate to a selectively beneficial allele is sufficiently high, Pennings and Hermisson (2006a) have shown, that it becomes likely, that a selective sweep is caused by several individuals. Such an event is called a soft sweep and the complementary event of a single origin of the beneficial allele, the classical case, a hard sweep. We give analytical expressions for the linkage disequilibrium (LD) between two neutral loci linked to the selected locus, depending on the recurrent mutation to the beneficial allele, measured by $D$ and $\hat{\sigma_D^2}$, a quantity introduced by Ohta and Kimura (1969), and conclude that the LD-pattern of a soft sweep differs substantially from that of a hard sweep due to haplotype structure. We compare our results with simulations. }, added-at = {2010-09-17T23:06:06.000+0200}, author = {Borck, Cornelia}, biburl = {https://www.bibsonomy.org/bibtex/2183d7b8adeadbc5125e174e7434d5b6f/peter.ralph}, description = {[1009.3150] The Effect of Recurrent Mutation on the Linkage Disequilibrium under a Selective Sweep}, interhash = {f682dd1363f66f9baf08f6cf7ee2bdce}, intrahash = {183d7b8adeadbc5125e174e7434d5b6f}, keywords = {linkage selective_sweep soft_sweeps}, note = {cite arxiv:1009.3150 Comment: 24 pages, 9 figures}, timestamp = {2010-09-17T23:06:06.000+0200}, title = {The Effect of Recurrent Mutation on the Linkage Disequilibrium under a Selective Sweep}, url = {http://arxiv.org/abs/1009.3150}, year = 2010 }