%0 Journal Article %1 Goldstein2010Genomics %A Goldstein, David B. %A Noor, Mohamed A. %D 2010 %I Nature Publishing Group %J Nature %K commentary genomics yeast %N 7291 %P 985--986 %R 10.1038/464985a %T Genomics: Lessons in complexity from yeast. %U http://dx.doi.org/10.1038/464985a %V 464 %X A challenge in biology is to understand complex traits, which are influenced by many genetic variants. Studies in yeast provide the prospect of analysing such genetic variation in detail in other organisms, including humans. Ever since the modern understanding of evolution and genetics in terms of natural selection and Mendelian inheritance was formulated, generations of scientists have struggled to explain the genetic bases and evolutionary significance of the remarkable variation among individuals, which is observed in many species. Despite considerable progress in finding the main genes that determine genetically simple traits, genetic variants of individually small effect that influence the so-called complex traits — which include height, weight and disorders such as neuropsychiatric diseases and cancers — have proved elusive.

@article{Goldstein2010Genomics, abstract = {A challenge in biology is to understand complex traits, which are influenced by many genetic variants. Studies in yeast provide the prospect of analysing such genetic variation in detail in other organisms, including humans. Ever since the modern understanding of evolution and genetics in terms of natural selection and Mendelian inheritance was formulated, generations of scientists have struggled to explain the genetic bases and evolutionary significance of the remarkable variation among individuals, which is observed in many species. Despite considerable progress in finding the main genes that determine genetically simple traits, genetic variants of individually small effect that influence the so-called complex traits — which include height, weight and disorders such as neuropsychiatric diseases and cancers — have proved elusive.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Goldstein, David B. and Noor, Mohamed A.}, biburl = {https://www.bibsonomy.org/bibtex/23f48bb93525462de583e4fc46a5fb4f1/karthikraman}, citeulike-article-id = {7021359}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/464985a}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/464985a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/20393546}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=20393546}, day = 15, doi = {10.1038/464985a}, interhash = {fbd5dc5a46e52da512188a112b1596ee}, intrahash = {3f48bb93525462de583e4fc46a5fb4f1}, issn = {1476-4687}, journal = {Nature}, keywords = {commentary genomics yeast}, month = apr, number = 7291, pages = {985--986}, pmid = {20393546}, posted-at = {2010-04-16 09:40:45}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Genomics: Lessons in complexity from yeast.}, url = {http://dx.doi.org/10.1038/464985a}, volume = 464, year = 2010 }