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The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters

, , , , , , and . Biochemistry, (2011)

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Messy biology and the origins of evolutionary innovations. Nature Chemical Biology, 6 (10): 692--696 (Oct 18, 2010)The moderately efficient enzyme: futile encounters and enzyme floppiness, , , and . Biochemistry, (2015)The 'evolvability' of promiscuous protein functions., , , , , and . Nature genetics, 37 (1): 73--76 (Jan 28, 2005)How Protein Stability and New Functions Trade Off., , , and . PLoS Comput. Biol., (2008)Conformational diversity and protein evolution--a 60-year-old hypothesis revisited., and . Trends Biochem. Sci., 28 (7): 361--368 (July 2003)Kemp elimination catalysts by computational enzyme design., , , , , , , , , and 4 other author(s). Nature, 453 (7192): 190--195 (May 2008)The moderately efficient enzyme: evolutionary and physicochemical trends shaping enzyme parameters, , , , , , and . Biochemistry, (2011)Noise-mean relationship in mutated promoters, , , , , , and . Genome Res., (2012)Mechanisms of Protein Sequence Divergence and Incompatibility, , and . PLoS Genet., (2013)Local fitness landscape of the green fluorescent protein., , , , , , , , , and 11 other author(s). Nat., 533 (7603): 397-401 (2016)