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Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido1,2,3-cdpurinediones

, , , , , , and . ChemMedChem, 1 (8): 891-902 (August 2006)Weyler, Stefanie Fulle, Friederike Diekmann, Martina Schumacher, Britta Hinz, Sonja Klotz, Karl-Norbert Muller, Christa E Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2006 Aug;1(8):891-902..

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8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists, , , , , and . Bioorg Med Chem, 6 (6): 707-19 (June 1998)Muller, C E Sandoval-Ramirez, J Schobert, U Geis, U Frobenius, W Klotz, K N England Bioorganic & medicinal chemistry Bioorg Med Chem. 1998 Jun;6(6):707-19..Biochemical and proteomic analysis of the magnetosome membrane in Magnetospitillum gryphiswaldense, , , , , , , and . Appl. Environ. Microbiol., 70 (2): 1040 -- 1050 (February 2004)Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists, , , , , and . J Med Chem, 43 (3): 440-8 (February 2000)Sauer, R Maurinsh, J Reith, U Fulle, F Klotz, K N Muller, C E In Vitro Research Support, Non-U.S. Gov't United states Journal of medicinal chemistry J Med Chem. 2000 Feb 10;43(3):440-8..Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido1,2,3-cdpurinediones, , , , , , and . ChemMedChem, 1 (8): 891-902 (August 2006)Weyler, Stefanie Fulle, Friederike Diekmann, Martina Schumacher, Britta Hinz, Sonja Klotz, Karl-Norbert Muller, Christa E Research Support, Non-U.S. Gov't Germany ChemMedChem ChemMedChem. 2006 Aug;1(8):891-902..7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists, , , , , and . J Med Chem, 43 (24): 4636-46 (November 2000)Hess, S Muller, C E Frobenius, W Reith, U Klotz, K N Eger, K In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2000 Nov 30;43(24):4636-46..A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists, , , , , and . J Med Chem, 49 (14): 4384-91 (July 2006)Yan, Luo Bertarelli, Daniela C G Hayallah, Alaa M Meyer, Heiko Klotz, Karl-Norbert Muller, Christa E In Vitro Research Support, Non-U.S. Gov't United States Journal of medicinal chemistry J Med Chem. 2006 Jul 13;49(14):4384-91..