%0 Journal Article %1 sahoo2019metabolite %A Sahoo, S %A Ravi Kumar, R K %A Nicolay, B %A Mohite, O %A Sivaraman, K %A Khetan, V %A Rishi, P %A Ganesan, S %A Subramanyan, K %A Raman, K %A Miles, W %A Elchuri, S V %D 2019 %J FEBS Lett %K myown %N 1 %P 23-41 %R 10.1002/1873-3468.13294 %T Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma %U https://www.ncbi.nlm.nih.gov/pubmed/30417337 %V 593 %X Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in�vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.

@article{sahoo2019metabolite, abstract = {Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in�vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.}, added-at = {2019-02-10T15:54:29.000+0100}, author = {Sahoo, S and Ravi Kumar, R K and Nicolay, B and Mohite, O and Sivaraman, K and Khetan, V and Rishi, P and Ganesan, S and Subramanyan, K and Raman, K and Miles, W and Elchuri, S V}, biburl = {https://www.bibsonomy.org/bibtex/2bfb9bd46463772c47c2ecd07257ff644/karthikraman}, description = {Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma. - PubMed - NCBI}, doi = {10.1002/1873-3468.13294}, interhash = {910f4596de609292b08b2c8135a6756d}, intrahash = {bfb9bd46463772c47c2ecd07257ff644}, journal = {FEBS Lett}, keywords = {myown}, month = jan, number = 1, pages = {23-41}, pmid = {30417337}, timestamp = {2019-02-10T15:54:29.000+0100}, title = {Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30417337}, volume = 593, year = 2019 }