Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in�vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.
Description
Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma. - PubMed - NCBI
%0 Journal Article
%1 sahoo2019metabolite
%A Sahoo, S
%A Ravi Kumar, R K
%A Nicolay, B
%A Mohite, O
%A Sivaraman, K
%A Khetan, V
%A Rishi, P
%A Ganesan, S
%A Subramanyan, K
%A Raman, K
%A Miles, W
%A Elchuri, S V
%D 2019
%J FEBS Lett
%K myown
%N 1
%P 23-41
%R 10.1002/1873-3468.13294
%T Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma
%U https://www.ncbi.nlm.nih.gov/pubmed/30417337
%V 593
%X Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in�vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.
@article{sahoo2019metabolite,
abstract = {Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in�vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.},
added-at = {2019-02-10T15:54:29.000+0100},
author = {Sahoo, S and Ravi Kumar, R K and Nicolay, B and Mohite, O and Sivaraman, K and Khetan, V and Rishi, P and Ganesan, S and Subramanyan, K and Raman, K and Miles, W and Elchuri, S V},
biburl = {https://www.bibsonomy.org/bibtex/2bfb9bd46463772c47c2ecd07257ff644/karthikraman},
description = {Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma. - PubMed - NCBI},
doi = {10.1002/1873-3468.13294},
interhash = {910f4596de609292b08b2c8135a6756d},
intrahash = {bfb9bd46463772c47c2ecd07257ff644},
journal = {FEBS Lett},
keywords = {myown},
month = jan,
number = 1,
pages = {23-41},
pmid = {30417337},
timestamp = {2019-02-10T15:54:29.000+0100},
title = {Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma},
url = {https://www.ncbi.nlm.nih.gov/pubmed/30417337},
volume = 593,
year = 2019
}