BibSonomy bookmarks for /user/bshanks

Caseware Docs

bshanks — 2026-10-27T07:32:29+01:00

https://www.caseware.com/docs

Interpretable Context Methodology - Google Search

bshanks — 2026-10-27T07:32:16+01:00

https://www.google.com/search?client=firefox-b-1-d&channel=entpr&q=Interpretable+Context+Methodology

Full Precision Calculator

bshanks — 2026-10-21T07:34:20+02:00

https://www.mathsisfun.com/calculator-precision.html

Two other commonalities among dementias are neuroinflammation and reduced brain glucose metabolism

bshanks — 2026-10-14T06:35:56+02:00

It is common on autopsy to find several of these brain pathologies, called mixed dementia. Two other commonalities among dementias are neuroinflammation and reduced brain glucose metabolism. Both can worsen the protein and tangle deposits. Glucose is the predominant fuel for the brain. Abnormal brain glucose uptake begins decades before obvious symptoms and is known since the 1980s but virtually ignored by the "baptists" and "tauists", and funders of research. Work by Dr. Stephen Cunnane’s group has shown a gap between how much energy the brain needs and how much is available even in cognitively normal older adults. This worsens with mild cognitive impairment and accelerates in Alzheimer's. They and others have shown that an alternative fuel, ketones, are taken up normally in mild cognitive impairment and Alzheimer's. Studies show that increased blood ketones from a ketogenic diet, ketone supplements, and fatty acids like medium-chain triglycerides (MCTs) substantially increase ketones in gray and white matter. A central molecule acetyl-CoA is produced from glucose or ketones by different pathways. Acetyl-CoA is needed to make acetylcholine, a brain chemical involved in memory and learning that is deficient in Alzheimer's. The brain energy issue is fundamental to most dementias; if corrected, existing drugs that increase availability of acetylcholine and other drugs that failed in trials might be more effective. Ketones and MCTs also reduce inflammation.