Long polyglutamine chains have been associated with a number of neurodegenerative diseases. These include Huntington's disease, where expanded polyglutamine (PolyQ) sequences longer than 36 residues are correlated with the onset of symptoms. In this paper we study the folding pathway of a 54-residue PolyQ chain into a -helical structure. Transition path sampling Monte Carlo simulations are used to generate unbiased reactive pathways between unfolded configurations and the folded -helical structu...
R. Graham, and J. Caverlee. WI-IAT '08: Proceedings of the 2008 IEEE/WIC/ACM International Conference on Web Intelligence and Intelligent Agent Technology, page 141--147. Washington, DC, USA, IEEE Computer Society, (2008)
I. Szpektor, and I. Dagan. COLING '08: Proceedings of the 22nd International Conference on Computational Linguistics, page 849--856. Morristown, NJ, USA, Association for Computational Linguistics, (2008)
M. Tatu, M. Srikanth, and T. D'Silva. Proceedings of the ECML/PKDD 2008 Discovery Challenge Workshop, part of the European Conference on Machine Learning and Principles and Practice of Knowledge Discovery in Databases, page 96--107. (2008)