Editorial on the "Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial," which studied optimal medical treatment with or without percutaneous coronary intervention (PCI) for stable coronary disease.
While the cause of statin-associated myopathy is controversial, a central role for coenzyme Q10 (CoQ10 or ubiquinone) is slowly gaining acceptance. Statins have been shown to create an acquired CoQ10 deficiency.
M. Ungerer, M. Bohm, J. Elce, E. Erdmann, and M. Lohse. Circulation, 87 (2):
454-63(February 1993)Ungerer, M Bohm, M Elce, J S Erdmann, E Lohse, M J In Vitro Research
Support, Non-U.S. Gov't United states Circulation Circulation. 1993
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J. Schmitt, H. Schunkert, D. Birnbaum, and H. Aebert. Eur J Cardiothorac Surg, 22 (3):
415-20(September 2002)Schmitt, J P Schunkert, H Birnbaum, D E Aebert, H England European
journal of cardio-thoracic surgery : official journal of the European
Association for Cardio-thoracic Surgery Eur J Cardiothorac Surg.
2002 Sep;22(3):415-20..