The widespread use of Artabotrys aurantiacus in traditional medicine for the quest for well-being aroused attention for its potential risk to human and animal health. This study points out the acute and sub-chronic toxicological profile of Artabotrys aurantiacus leaves aqueous extract. The extract was prepared following the traditional healer’s method and orally administered to Wistar rats at a single dose of 5000 mg/kg or 50, 100, 200 and 400 mg/kg/day for 45 days for acute and sub-chronic tests, respectively. In acute toxicity, no behavioral disorder was observed in treated animals as compared to the control. The lethal dose of 50 was estimated to be higher than 5000 mg/kg and the extract was noted as slightly toxic. Similarly, no significant change in body weight nor biochemical parameters were observed after 45 days of repeated dosing of the extract. Histological study revealed that all tested doses induced no damage to the liver and kidney as compared to control. These findings indicate that the use of Artabotrys aurantiacus leaves aqueous extract at tested doses is not associated with any toxic effect.
We describe how innate and adaptive immune cascades trigger the release of cytokines and chemokines, resulting in the initiation and progression of atherosclerosis. We discuss how cytokines have direct and indirect effects on myocardial function.
Atherosclerosis is the predominant underlying pathology of cardiovascular disease...atherosclerotic lesions are characterized by abundance of immune cells and their effector molecules, eventually leading to unstable angina, myocardial infarction, or strok
The cellular and extracellular matrix accumulations that comprise the lesions of atherosclerosis are driven by local release of cytokines at sites of predilection for lesion formation, and by the specific attraction and activation of cells expressing rece
A relationship exists between cytokines and both leptin (L4146) and insulin ( I1507). Proinflammatory cytokines increase leptin levels while leptin regulates pro- and anti-inflammatory cytokine production.
Millions of Americans are deficient in the vital digestive enzyme called D6D (delta-6 desaturase) required to convert flax oil into EPA and GLA, the two nutrients that fight inflammation. Unlike flax seed oil, borage and fish oils do not require that prob
Inflammation: (Latin, inflammatio, to set on fire) is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.
Central neuropeptides, including corticotropin releasing factor and perhaps substance P as well, initiate a systemic stress mobilization response by activating the sympathetic nervous system, hypothalamic pituitary axis, and the renin angiotensin system,
Baseline values of C reactive protein, serum amyloid A protein, leucocyte count, and serum albumin were associated with one another as well as with future risk of coronary heart disease.
scientists reported that a person's risk of a heart attack is doubled if he or she produces a particular version of FLAP, known more technically as 5-lipoxygenase activating protein. A troublesome variant of this protein boosts production of the inflammat
Accumulating evidence supports the hypothesis that chronic low-grade inflammation and activation of the innate immune system are closely involved in the pathogenesis of the type 2 diabetes.
One hundred and fifty years after Whitman sang "the body electric," we can find in Whitman's fate some clues to the nature of aging. For much of his adult life, he complained of chronic headaches, fevers, and weakness. At the age of 55, he suffered a stro
Scientists have known that macrophages also appear in adipose, or fat, tissue. But their role in the tissue was once thought to be inconsequential. Now, these immune cells appear to be rushing to dead fat cells to mop them up. These macrophages emit poten
Inflammation is a complex biological process in response to cellular perturbation or injury. It is manifest clinically as pain, heat (fever), redness, and loss of tissue function. It serves the important helpful role of initiating the elimination of tumor
This study suggests, but can't prove, that omega-3 fats reduce levels of inflammation. But it offers one more reason to eat seafood a few times a week without worrying that the soy oil in your salad dressing will cancel out the seafood's benefits.
Elevated levels of c-reactive protein (CRP) are known to be associated with insulin resistance and metabolic syndrome in adults. A substantial prevalence of hyperinsulinaemia and elevated CRP levels have been shown in Indian young adults.
Underlying the body’s healing response is a process by which tissues inflame. Chronic inflammation, if left unchecked, can devastate the body’s tissues, especially in the vascular and nervous systems. Numerous natural products help control the inflamm
Underlying the body’s healing response is a process by which tissues inflame. Chronic inflammation, if left unchecked, can devastate the body’s tissues, especially in the vascular and nervous systems. Numerous natural products help control the inflamm
Inflammation destroys HA, and HA, injected into joints, decreases inflammation. In addition, it appears inflammation may reduce a cells ability to produce HA.
Researchers say circulating mononuclear cells (the largest type of white blood cell) and lymphocytes, exist in a proinflammatory state in obese persons known to be at increased risk of developing heart disease, diabetes, or both.
Exposure to secondhand smoke leads to inflammation and oxidation, representing another pathophysiologic mechanism for the development of atherosclerosis.
In conclusion, the daily supplementary intake of 500 mg green tea polyphenols did not have clear effects on blood glucose level, Hb Alc level, insulin resistance or inflammation markers. The positive correlation between the level of polyphenol intake and
V. Stel, F. Dekker, G. Tripepi, C. Zoccali, and K. Jager. Nephron. Clinical practice, 119 (1):
c83-8(January 2011)6597<m:linebreak></m:linebreak>CI: Copyright (c) 2011; JID: 101159763; 2011/06/15 aheadofprint; ppublish;<m:linebreak></m:linebreak>Anàlisi de supervivència; Introductori; Nefrologia.
K. Leffondré, K. Jager, J. Boucquemont, V. Stel, and G. Heinze. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29 (10):
1806-14(October 2014)Anàlisi de dades; Nefrologia; Introductori.
