Keeping individuals on antidepressants after remission or recovery of major depressive disorder is a common strategy to prevent relapse or recurrence. Preventive cognitive therapy (PCT) has been proposed as an alternative to maintenance antidepressant treatment, but whether its addition would allow tapering of antidepressants or enhance the efficacy of maintenance antidepressant treatment is unclear. We aimed to compare the effectiveness of antidepressants alone, with PCT while tapering off antidepressants, or PCT added to antidepressants in the prevention of relapse and recurrence.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Comment. In 1994, a randomised controlled trial introduced the sequential design in depression.1 In that trial, individuals with depression who had responded to drug treatment were randomly assigned to cognitive behavioural therapy or to clinical management while antidepressant drugs were tapered and discontinued.1 This design was subsequently used in a number of randomised controlled trials and was found to lead to significant benefits.2 The strategy is an intensive, two-stage approach in which one type of treatment (psychotherapy) is used to improve symptoms that another type of treatment (pharmacotherapy) was unable to affect.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Comment. The publication of our updated network meta-analysis1 about antidepressants for the acute treatment of major depression has generated a wide discussion in newspapers,2, 3 social media,4 and scientific journals.5 Based on 522 trials and more than 116 000 patients, this network meta-analysis of 21 drugs and placebo represents the most comprehensive analysis of the evidence base ever undertaken. We take the opportunity of this Comment not to repeat our findings but to reflect on the implications of this research and, most importantly, on what needs to be done next to improve the outcome of patients with major depression.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Recent data suggest that anxiety disorders are as often comorbid with bipolar disorder (BD) as with unipolar depression. The literature on panic disorder (PD) comorbid with BD has been systematically reviewed and subject to meta-analysis.. To read the full article, log in using your NHS OpenAthens details.
The association of childhood maltreatment and suicide has been extensively examined within the population. Depression figures as a main cause for the elevated suicide rate in advanced ages and is often related to childhood maltreatment. The purpose of the present study was to examine the relationship between childhood maltreatment subtypes and suicide risk, testing geriatric depression as a moderator.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
Treatment-resistant depression (TRD) is a serious and relatively common clinical condition. Lack of consensus on defining and staging TRD remains one of the main barriers to understanding TRD and approaches to intervention. The Maudsley Staging Method (MSM) is the first multidimensional model developed to define and stage treatment-resistance in “unipolar depression”. The model is being used increasingly in treatment and epidemiological studies of TRD and has the potential to support consensus. Yet, standardised methods for rating the MSM have not been described adequately. The aim of this report is to present standardised approaches for rating or completing the MSM.
Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and whether the findings replicate in brain tissue.. Login at top right hand side of page using your SSSFT NHS OpenAthens for full text. SSOTP- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major depression, including suicidality, among individuals at imminent suicide risk.. Login at top right hand side of page using your SSSFT NHS OpenAthens for full text. SSOTP- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
Major depressive disorder (MDD) is a mixed disorder with the highly irregular course, inconsistent response to treatment and has no well-known mechanism for the pathophysiology. Major causes of depression are genetic, neurobiological, and environmental. However, over the past few years, altered serum levels of macro-minerals (MM) and trace elements (TE) have been recognized as major causative factors to the pathogenesis of many mental disorders. The purpose of this study was to determine the serum levels of MM (calcium and magnesium) and TE (copper, iron, manganese, selenium, and zinc) in MDD patients and find out their associations with depression risk.
Depression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol into account.
Bona fide psychotherapy approaches are effective treatments for generalized anxiety disorder (GAD) compared to no-treatment conditions. Treatment manuals and protocols allow a relatively high degree of freedom for the way therapists implement these overall treatment packages and there is a systematic lack of knowledge on how therapists should customize these treatments. The present study experimentally examines two implementation strategies of customizing a bona fide psychotherapy approach based on a 16 session time-limited cognitive-behavioral therapy (CBT) protocol and their relation to the post-session and ultimate treatment outcomes.
Letter. Login at top right hand side of page using your SSSFT NHS OpenAthens for full text. SSOTP- Please contact the library to receive a copy of this article - http://bit.ly/1Xyazai
The aims of the study were to investigate the prevalence of long-term use of benzodiazepines in patients taking antidepressants and to identify the risk factors associated with the prolonged use of benzodiazepines. Open Access Article
Patients who require a switch in their antidepressant therapy may have different clinical profiles and treatment needs compared with patients initiating or maintaining a first-line antidepressant therapy.
The Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (MDD) (PERFORM) study was a 2-year observational cohort study in outpatients with MDD in five European countries.
Researchers carried out a review of all the studies that had looked at depressive symptoms arising when people who regularly exercised for a period of time suddenly stopped. Contrary to the Mail's headline, none of the studies the researchers looked at included people with a confirmed diagnosis of depression.
The article offers information on several topics including a meeting of the British Association for Counselling & Psychotherapy (BACP), antidepressants, and sexual harassment. Topics discussed include the annual general meeting (AGM) of the BACP held in November 2017, the increased usage of antidepressants in Great Britain, and the reports about sexual harassment in Great Britain's parliament and entertainment industry.. To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.
The article presents the findings of a survey conducted by nonprofit organization Age UK focusing on the mental health of older adults in Great Britain, discussing the prevalence of depression and anxiety among them and trigger of mental health issues due to the death of loved ones.. To read the full article, log in using your SSSFT NHS OpenAthens details. SSOTP - You can request a copy of this article by replying to this email. Please ensure you are clear which article you are requesting.