The placebo‐controlled, relapse prevention studies (PCRPS) have recently been recently been singled out as redundant, disproportionately harmful, unnecessary and therefore ethically impermissible (1). The logic of comparison behind PCRPS has also been questioned as they apply different methodological procedures, such as duration of treatment prior to randomization and/or different treatment discontinuation strategies (2). Furthermore, there seems to be a real threat that withdrawal syndromes and other overlapping phenomena (such as rebound effects) cannot be reliably distinguished from relapse (as primary endpoint), and as such have high confounding potential (2).. To read the full article, log in using your NHS Athens details. To access full-text: click “Log in/Register” (top right hand side). Click ‘Institutional Login’ then select 'OpenAthens Federation', then ‘NHS England’. Enter your Athens details to view the article.