Antiseizure medications (ASMs) are the second most widely prescribed psychotropic for people with intellectual disabilities in England. Multiple psychotropic prescribing is prevalent in almost half of people with intellectual disabilities on ASMs. This analysis identifies limited evidence of ASM benefit in challenging behaviour management and suggests improvements needed to inform clinical practice. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
To minimise infection during COVID-19, the clozapine haematological monitoring interval was extended from 4-weekly to 12-weekly intervals in South London and Maudsley NHS Foundation Trust. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The authors investigated transitions to schizophrenia spectrum or bipolar disorder following different types of substance-induced psychosis and the impact of gender, age, number of emergency admissions related to substance-induced psychosis, and type of substance-induced psychosis on such transitions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
CYP2C19 is a hepatic enzyme involved in the metabolism of antidepressants associated with increased gastrointestinal bleed (GIB) risk. The aim of our study is to explore a possible association between loss of function CYP2C19 genotypes and GIB in South-Asian ancestry participants prescribed antidepressants. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study aims to explore the views and experiences of pharmacist independent prescribing (IPs) regarding prescribing errors and strategies to mitigate errors in practice. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
In the United Kingdom (UK) anti-seizure medications (ASMs) are the second most widely prescribed psychotropic agent for PwID. However, it is unclear what the current evidence and patterns is on current prescribing of ASMs including when and how a case is made to withdraw them. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
We aimed to systematically synthesize the current published literature on neonatal growth outcomes associated with antiseizure medications (ASMs) use during pregnancy. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This State of the Nation Report looks at product information for medicines, the needs and preferences of patients and healthcare professionals, and how people engage with this information.
Opinion piece. The upcoming workforce plan from NHS England is expected to set out a future where there are not only more health care staff, but also different types of staff, which could encompass new skills or new professions. If it is not simply 'more of the same’, what could this different future look like? We already have one example well in train.
This study aimed to establish a prediction model of quetiapine concentration in patients with schizophrenia and depression, based on real-world data via machine learning techniques to assist clinical regimen decisions. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This study utilized physiologically based pharmacokinetic (PBPK) and pharmacodynamic (PD) modeling to further examine the underlying mechanisms of anxiety treatment and addiction. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The aim of this systematic review was to create an overview of all factors reported in the literature, both protective and facilitating, as influencing in-hospital prescribing errors. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Anticholinergic burden is weakly associated with poorer cognition, but there is little evidence for associations with brain structure. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The Liverpool Causality Assessment Tool is a more sensitive tool than the Naranjo Scale in the assessment of possible adverse drug reactions but both tools have poor specificity. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
The findings from this study confirm the importance of age-related risperidone dose adjustments and argue strongly for therapeutic drug monitoring in the initial stages of treatment, to identify those at greatest risk of toxicity. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Guidance on clozapine dosing in treatment-resistant schizophrenia is based largely on data from White young adult males. This study aimed to investigate the pharmacokinetic profiles of clozapine and N-desmethylclozapine (norclozapine) across the age range, accounting for sex, ethnicity, smoking status, and body weight. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
This retrospective cohort study aimed to evaluate the effect of the interaction between methotrexate and glucocorticoids on the risk of developing bacterial infections in patients with rheumatoid arthritis (RA) using biological disease-modifying antirheumatic drugs (bDMARDs). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
“BRAINS” encapsulates the higher-level principles to think about relating to the proposed drug, the patient and their condition (use your BRAINS: Benefits, Risks, Adverse Effects, Interactions, Necessary prophylaxis, Susceptibilities) before prescribing and “AIMS”, the action principles around prescribing/giving the drug (AIMS: Administering, Informing, Monitoring and Stopping). To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient perspectives on strategies to improve adherence. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.
Drug Hypersensitivity reactions (DHRs) are type B adverse drug reactions (ADRs) traditionally defined as unpredictable, dose independent and not related to the drug pharmacology. This review attempts at summarizing the available evidence to further illustrate the pathophysiology of DHRs. To read the full article, choose Open Athens “Institutional Login” and search for “Midlands Partnership”.