Among organic amendments, compost is well known for its effectiveness on agricultural productivity increase but little is diffused about vermicompost efficacy. The present study aimed to evaluate the benefits of vermicompost from animal wastes on Lagenaria siceraria productivity and its seeds quality compared to compost. Thus, a field experiment was carried out under randomized complete block design with three replicates in Côte d’Ivoire by using compost and vermicompost as fertilizers. The agronomic parameters as “time of fruits maturity, number of fruits per plant, weigh of fruit, yield and heavy metal contents in the seeds were evaluated. For a same type of waste, shorter time to maturity, larger number of fruits per plant, larger number of seeds per fruit, heavier fruits and seeds and higher yields were obtained with vermicompost compared to compost. Heavy metals contents in seeds from vermicomposts were lower than those from composts with the same type of waste. Contents of heavy metals in the seeds from plots that received vermicomposts were all below the maximum residue limits recommended by the Codex Alimentarius. Our results indicated that vermicompost improved more the yield of L. siceraria and its seeds quality compared to compost, and hence could be recommended to peasants rather than compost.