Findings  In this cross-sectional study, relative to offspring of healthy parents, offspring of parents with bipolar disorder had significantly greater right rostral anterior cingulate cortex activity when regulating attention away from happy faces, which was significantly positively correlated with affective lability symptom severity. Additionally, offspring of parents with bipolar disorder had significantly greater amygdala to left caudal anterior cingulate cortex functional connectivity to fearful faces relative to offspring of parents without bipolar disorder but with other psychiatric disorders.. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai