Comment. Neuroimaging has affected our understanding of psychiatric illnesses by shifting conceptualisations towards brain models of disease. However, this process has not unfolded without missteps along the way, and serious concerns about replicability continue to plague the field.1,2 From these concerns, researchers strive to find new ways to improve science, and over the years, a key takeaway point has become clear—as long as studies with small samples remain the standard, the field will continue to struggle with false positives, adding more noise to an already complex and unharmonious science. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai