The Django REST interface makes it easy to offer private and public APIs for existing Django models. New generic views simplify data retrieval and modification in a resource-centric architecture and provide model data in formats such as XML, JSON and YAML with very little custom code.
PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.