Researchers repeatedly discovered primary pharmaceutical contaminants, their metabolites, and transformation products in aquatic ecosystems. Body metabolism may not convert consumed pharmaceuticals to their metabolic elements before excretion. In this case, clinical and industrial wastes ensure their presence in the environment. Nevertheless, conventional wastewater treatment methods are ineffective for removing pharmaceutical wastes. Once in the ecosystem, they alter the physiological response of nontarget exposed aquatic and even terrestrial organisms due to induced toxicity.