The traditional “drug-event combination” approach is too simplistic for complex side effects such as behavioural changes. We must adjust our methodology to address this intricacy.
Reports in VigiBase, the WHO global database of individual case safety reports, often concern multi-drug users at risk of drug-drug interactions, and should be valuable for finding interaction signals. A dedicated signal detection algorithm, vigiRank for Interactions, has been developed at Uppsala Monitoring Centre.