bookmarks (hide)1026
- The CANHEART ‘big data’ research initiative is aimed at measuring and improving cardiovascular health and the quality of ambulatory cardiovascular care provided in Ontario, Canada using the population-based CANHEART cohorts. The CANHEART cohorts were created through the linkage of 19+ routinely collected health administrative, vital statistics, survey and laboratory databases housed at ICES. The strength of these cohorts lies in the large sample size, containing information on 9.8 million Ontarians age 20-105 years, and diversity of the linked databases. Building upon the insights gained to date through the CANHEART work, we have recently launched a new CANHEART SPOR project aimed at leveraging big data to conduct innovative cardiovascular clinical trials. We aim to: 1) undertake a pragmatic cluster randomized registry-based clinical trial to improve lipid-management amongst intermediate-and high-risk patients residing in high-risk health regions in Ontario (called CHOICES), and 2) develop novel algorithms for measuring clinical outcomes in clinical trials using health-related databases and compare whether they are as accurate as traditional event ascertainment methods in a prospective clinical trial (called INVESTED). These projects will be undertaken by an interdisciplinary team consisting of experts in administrative health databases, implementation science, clinical trials, knowledge translation and patient engagement.
- Researcher Paula Byrne writes on what she and her colleagues learned from a meta-analysis of 21 clinical trials involving 140,000 patients. Our study highlights that patients and doctors need to be supported to make decisions about treatments using evidence from all available studies and presented in a format that helps them understand potential benefits.
- Tutorial that I did to learn R. Contribute to yukikongju/R-Tutorial development by creating an account on GitHub.
- This article recommends 33 free books which will teach you the basics of R, how to produce amazing plots, how to apply R to lots of disciplines, and how to efficiently program in R.
- The bookdown package is an open-source R package that facilitates writing books and long-form articles/reports with R Markdown.
- This book will teach you how to do data science with R: You’ll learn how to get your data into R, get it into the most useful structure, transform it, visualise it and model it. In this book, you will find a practicum of skills for data science. Just as a chemist learns how to clean test tubes and stock a lab, you’ll learn how to clean data and draw plots—and many other things besides. These are the skills that allow data science to happen, and here you will find the best practices for doing each of these things with R. You’ll learn how to use the grammar of graphics, literate programming, and reproducible research to save time. You’ll also learn how to manage cognitive resources to facilitate discoveries when wrangling, visualising, and exploring data.
- El Objetivo del paquete aprendeR es facilitar que nuevas personas puedan R moderno con una curva de aprendizaje baja, y evitando que el inglés sea una barrera para que se puedan centrar en el aprendizaje competencial de R. Se incluyen traducciones al castellano de tutoriales presentes en otros paquetes (learnr, tutorial.helpers, r4ds.tutorials, ...), y eventualmente nuevos tutoriales más adelante.
- Reports in VigiBase, the WHO global database of individual case safety reports, often concern multi-drug users at risk of drug-drug interactions, and should be valuable for finding interaction signals. A dedicated signal detection algorithm, vigiRank for Interactions, has been developed at Uppsala Monitoring Centre.
- Repàs toxicitat CV AINE
- The WEB-RADR project developed three mobile applications (apps) enabling patients, caregivers, and healthcare professionals to report adverse drug reactions (ADRs) and receive up-to-date information and news alerts. UK (Yellow Card) - launched 14 July 2015 Netherlands (LAREB) - launched 29 January 2016 Croatia (HALMED) - launched 18 May 2016 Key features: A convenient alternative to paper or electronic…
- Cal informar les dones en edat fèrtil i que poden estar embarassades dels riscos de l’ús de pregabalina, que l’embaràs ha de ser planificat i que han d’emprar mesures anticonceptives durant el tractament. Sempre s’hauran de ponderar els beneficis i els riscos del tractament i, si cal tractar amb pregabalina durant l’embaràs, es farà a la dosi més baixa possible i fent una supervisió més estricta de la persona. Pregabalin (Lyrica): findings of safety study on risks during pregnancy. Drug Safety Update. Medicines and Healthcare products Regulatory Agency. Published 19 April 2022.
- El metamizole s’associa a un risc de dany hepàtic gairebé 2 vegades superior a paracetamol i augmenta el risc de dany fins a 5 vegades respecte a no consumir el fàrmac. És més freqüent en dones i en tractaments a partir de 9 dies de durada. Per aquest motiu, se n’hauria de restringir l’ús a casos de dolor agut. Hedenmalm K, Pacurariu A, Slattery J, Kurz X, Candore G, Flynn R. Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users. Drug Saf. 2021 Sep;44(9):973-985.
- Una revisión sistemática exhaustiva de todas las evidencias disponibles de ensayos controlados aleatorizados sobre vacunas contra la covid-19 hasta noviembre de 2021 ha concluido que la mayoría protegen contra la infección y la enfermedad grave o crítica causada por el virus. La revisión, una colaboración de expertos independientes de varios países, también observó que hubo poca o ninguna diferencia entre el número de personas que experimentaban efectos secundarios graves después de la vacunación en comparación con las que no estaban vacunadas.
- Desde el principio de la humanidad las distintas civilizaciones han perseguido el conocimiento. Nuestra civilización proviene de la civilización indoeuropea. Se dice que una las formas de reconocer una misma civilización es perseguir algunos términos a través del lenguaje. Por ejemplo la palabra "conocimiento" o "sabiduría" en sánscrito se llama vidya. La palabra es idéntica a otra palabra en griego idé. Del latín conocemos la palabra video que entre los romanos significa ver. En inglés conocemos las palabras como wise y wisdom en alemán wissen y en noruego viten que tiene la misma raíz que la palabra hindú vidya , la griega idé y la latina video.
- Chapter 9: Signal detection methodology and application
- Tradueix el missatge Desactiva per a: espanyol Los criterios de Bradford Hill se han utilizado para describir la causalidad en epidemiología. Un excelente artículo de Holger Schunemann y Guyatt entre otros, pone de manifiesto como la clasificación GRADE intenta cumplir con estos criterios, además de revalorizar el uso de los estudios observacionales.
- Tramadol es un opioide débil con un consumo elevado desde el momento de su puesta en el mercado en España en el año 1998. La aparición en el mercado de combinaciones de tramadol con paracetamol y dexketoprofeno, supuestamente a dosis bajas, ha hecho que se tenga una falsa sensación de seguridad y no se tenga conciencia de los riesgos del consumo crónico de tramadol. En los últimos años han aparecido numerosas publicaciones haciéndose eco de problemas de seguridad, mal uso y comercio ilícito que de este fármaco se está haciendo a nivel mundial. El tramadol se ha incluido en el Plan de optimización de la utilización de analgésicos opioides en dolor crónico no oncológico en el sistema nacional de salud aprobado el 13 de julio de 2021 debido a los problemas de seguridad identificados que conlleva el uso crónico de este fármaco. La prevalencia de consumo de tramadol a nivel nacional en el grupo de 15-64 años en el año 2019 fue de 7,2% (6,3 en hombres y 8,2 en mujeres1 ).
- Una campanya de màrqueting de fa 60 anys va introduir el mite de les 10.000 passes, que ha quedat com un sinònim d'exercici saludable
- Una revisión sistemática sobre 46 estudios confirma que la miocarditis por vacuna es más común en jóvenes, varones, luego de la segunda dosis. Esto sugiere que en el caso de vacunar debiera elegirse otras plataformas si están disponibles, o bien no dar la vacuna de Moderna, además de prolongar el rango interdosis a 56 días. Los estudios primarios se consideran de baja calidad por ser observacionales, pero son consistentes y establecen un gradiente dosis y aparición del efecto lo que es indicio de causalidad.
- Tomado de Universo AbiertoLister, Heather. How to Define Success in Your Makerspace. Demco Ideas & inspiration, 2019Texto completoUno de los debates más acalorados en la educación de los creadores gira en torno a la evaluación.¿Evaluar o no evaluar?No es ningún secreto que la educación está al borde de la obsesión por las evaluaciones.
- "...la docencia híbrida no debe centrarse únicamente en alternar educación presencial con educación a distancia mediada por tecnología, sino que debe promover un uso más efectivo en el aula de las posibilidades de aprendizaje que ofrecen las herramientas digitales, con un mejor aprovechamiento de la tecnología para crear experiencias centradas en el alumno, que sean personalizadas, relevantes y atractivas" (BID, 2021: 7).
- The relationship between large-group classroom attendance by students and test achievement in problem-based learning (PBL) curricula is unclear. This study examined the correlation between attendance at resource sessions (hybrid lectures in the PBL curriculum) and test scores achieved in pharmacology and determined whether the score achieved was related to student gender. A cross-sectional observational study over one academic year of 1404 pre-clerkship medical students was performed. Class attendance during pharmacology resource sessions and MCQ test scores achieved in pharmacology were analysed. The percentage of students’ attendance in resource sessions declined over three years of the programme, from 78.7 ± 27.5 in unit I to 22.1 ± 35.6 (mean ± SD) in unit IX. A significant but weakly positive correlation was evident between attendance and achievement in pharmacology (r = 0.280; p < 0.0001). The mean score of the students who attended > 50% of the resource sessions was significantly higher (p < 0.0001). Students who attended ≤50% were more likely to achieve lower tertile scores. The mean score achieved and the number of higher tertile scorers were higher among students who attended > 50% of the resource sessions. Although female students’ attendance was significantly higher, no significant gender-related differences in either mean scores or top grades achieved were found. In a PBL curriculum, the classroom attendance of students in pharmacology declined during the pre-clerkship phase. A weak positive correlation was found between attendance and academic achievement, as measured by MCQ test scores. Factors other than motivation and attendance may confound gender-based academic performance and merit further research.
- The ninth annual Be Medicinewise Week is encouraging Australians to get to know the language of medicines. Understanding and communicating about medicines is key to getting the most out of them, safely.
- Christopher Haynes says it's time to stop asking if online learning is effective. It is time to stop asking if online learning is as “effective” as traditional face-to-face learning. The question has been asked and answered. Asking it over and over again will not yield the responsive, localized, and collaborative answers we need to facilitate meaningful education for an increasingly diverse body of learners.
- The EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network is an international initiative that seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines. It is the first coordinated attempt to tackle the problems of inadequate reporting systematically and on a global scale; it advances the work done by individual groups over the last 15 years.
- En los últimos años la crisis económica ha causado estragos en el Sistema Nacional de Salud de España. Esto, no es noticia. Pero sí lo es saber de qué manera se hicieron los recortes, como nos cuenta Sergio Minué en su blog, recortes que se han cebado fundamentalmente con la atención primaria y que, visto lo visto,…
- "Alzheimer's drug may keep late-stage sufferers out of nursing homes," The Guardian reports. A study found people with Alzheimer's who continued to take a drug called donepezil were less likely to be admitted into care than people who stopped taking it.
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- 1Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021(2024)
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