Editorial commentary. MCI is a clinical diagnostic term for elderly subjects with impaired cognitive performance that does not significantly interfere with independent living. MCI, an intermediate condition between normal cognition and dementia, is typically divided into amnestic or non-amnestic subtypes, with single-domain or multidomain distinctions. After the diagnosis, some subjects with MCI develop Alzheimer’s disease (AD) dementia or other dementias resulting from non-AD brain diseases, whereas a substantial proportion of subjects may later be diagnosed as cognitively normal or remain diagnosed with MCI even after a prolonged period. Although the reason for the various clinical courses in subjects with MCI remains unclear, a recent large clinicopathological longitudinal study revealed disease …... To read the full article, log in using your NHS OpenAthens details.