This study evaluated rates of all-cause mortality and self-harm in association with clozapine treatment in individuals with treatment-resistant schizophrenia. Login at top right hand side of page using your SSSFT NHS Athens for full text.
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia. The aim of this study was to identify additional genetic factors (i.e., “second hits”) that may contribute to schizophrenia expression. Login at top right hand side of page using your SSSFT NHS Athens for full text.
The authors assessed the efficacy, safety, and tolerability of MIN-101, a compound with affinities for sigma-2 and 5-HT2A receptors and no direct dopamine affinities, in comparison with placebo in treating negative symptoms in stabilized patients with schizophrenia. Login at top right hand side of page using your SSSFT NHS Athens for full text.
Blood–brain barrier pathology is recognised as a central factor in the development of many neurological disorders, but much less is known about the role of the blood–brain barrier in psychiatric disorders. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai
The objective of the study was to compare the predictive utility of three commonly used functioning measures for people with serious mental illness in the prediction of independent living status. To read the full article, log in using your SSSFT NHS OpenAthens details.
CBTp is recommended by the National Institute for Clinical Excellence for service users with psychosis at every stage of their illness, but provision of this intervention is not widespread. This narrative literature review critically appraised six primary studies, all of which view CBTp through the eyes of service users, revealing their perceptions of CBTp experiences and of their therapists. To read the full article, log in using your NHS OpenAthens details.
Journal of Abnormal Psychology126.5 (Jul 2017): 694-711.
Motivational and hedonic impairments are core features of a variety of types of psychopathology. An important aspect of motivational function is reinforcement learning (RL), including implicit (i.e., outside of conscious awareness) and explicit (i.e., including explicit representations about potential reward associations) learning, as well as both positive reinforcement (learning about actions that lead to reward) and punishment (learning to avoid actions that lead to loss). Here we present data from paradigms designed to assess both positive and negative components of both implicit and explicit RL, examine performance on each of these tasks among individuals with schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis, and examine their relative relationships to specific symptom domains transdiagnostically. To read the full article, log in using your NHS OpenAthens details.