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1Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro 1,2,4-triazolo 3,4-f-purines as potential adenosine receptor antagonists
G. Pastorin, C. Bolcato, B. Cacciari, S. Kachler, K. Klotz, C. Montopoli, S. Moro, and G. Spalluto. Farmaco, 60 (4): 299-306 (April 2005)Pastorin, Giorgia Bolcato, Chiara Cacciari, Barbara Kachler, Sonja Klotz, Karl-Norbert Montopoli, Christian Moro, Stefano Spalluto, Giampiero Research Support, Non-U.S. Gov't Italy Farmaco (Societa chimica italiana : 1989) Farmaco. 2005 Apr;60(4):299-306..
15 years ago by @pharmawuerz
show all tags
Binding
Cricetinae
&
Sites
Rats
Membrane/metabolism
Protein
Animals
Receptor
Cyclization
Line
Relationship
Triazoles/*chemical
Models,
Structure-Activity
Cyclase/metabolism
inhibitors
Cricetulus
Purines/*chemical
Adenylate
Purinergic
Molecular
P1/*antagonists
synthesis/chemistry/pharmacology
Structure
Cell
BindingCricetinae&SitesRatsMembrane/metabolismProteinAnimalsReceptorCyclizationLineRelationshipTriazoles/*chemicalModels,Structure-ActivityCyclase/metabolisminhibitorsCricetulusPurines/*chemicalAdenylatePurinergicMolecularP1/*antagonistssynthesis/chemistry/pharmacologyStructureCell
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1Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites
L. Michielan, C. Bolcato, S. Federico, B. Cacciari, M. Bacilieri, K. Klotz, S. Kachler, G. Pastorin, R. Cardin, A. Sperduti and 2 other author(s). Bioorg Med Chem, 17 (14): 5259-74 (July 2009)Michielan, Lisa Bolcato, Chiara Federico, Stephanie Cacciari, Barbara Bacilieri, Magdalena Klotz, Karl-Norbert Kachler, Sonja Pastorin, Giorgia Cardin, Riccardo Sperduti, Alessandro Spalluto, Giampiero Moro, Stefano Research Support, Non-U.S. Gov't England Bioorganic & medicinal chemistry Bioorg Med Chem. 2009 Jul 15;17(14):5259-74. Epub 2009 May 21..
15 years ago by @pharmawuerz
show all tags
Binding
&
Sites
A3/*antagonists
Pyrazoles/chemical
Protein
Chemical
Receptor
A2A/*antagonists
inhibitors/chemistry/*metabolism
Discovery
Relationship
Models,
Structure-Activity
Adenosine
Static
Intelligence
Humans
Triazoles/chemical
Electricity
Pyrimidines/chemical
synthesis/*chemistry/*pharmacology
synthesis/chemistry/pharmacology
*Artificial
Drug
Binding&SitesA3/*antagonistsPyrazoles/chemicalProteinChemicalReceptorA2A/*antagonistsinhibitors/chemistry/*metabolismDiscoveryRelationshipModels,Structure-ActivityAdenosineStaticIntelligenceHumansTriazoles/chemicalElectricityPyrimidines/chemicalsynthesis/*chemistry/*pharmacologysynthesis/chemistry/pharmacology*ArtificialDrug
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1The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist
S. Moro, M. Bacilieri, B. Cacciari, C. Bolcato, C. Cusan, G. Pastorin, K. Klotz, and G. Spalluto. Bioorg Med Chem, 14 (14): 4923-32 (July 2006)Moro, Stefano Bacilieri, Magdalena Cacciari, Barbara Bolcato, Chiara Cusan, Claudia Pastorin, Giorgia Klotz, Karl-Norbert Spalluto, Giampiero In Vitro Research Support, Non-U.S. Gov't England Bioorganic & medicinal chemistry Bioorg Med Chem. 2006 Jul 15;14(14):4923-32. Epub 2006 Mar 29..
15 years ago by @pharmawuerz
show all tags
Binding
Techniques
&
Sites
A3/*antagonists
Protein
Analysis
Receptor
User-Computer
Chemistry
Relationship
Models,
Structure-Activity
Adenosine
inhibitors/chemistry
Conformation
Static
Interface
Least-Squares
Humans
Molecular
Design
Electricity
Combinatorial
Pyrimidines/chemical
synthesis/chemistry/pharmacology
Quantitative
Drug
BindingTechniques&SitesA3/*antagonistsProteinAnalysisReceptorUser-ComputerChemistryRelationshipModels,Structure-ActivityAdenosineinhibitors/chemistryConformationStaticInterfaceLeast-SquaresHumansMolecularDesignElectricityCombinatorialPyrimidines/chemicalsynthesis/chemistry/pharmacologyQuantitativeDrug
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1Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro 1,2,4-triazolo 3,4-f-purines as adenosine receptor antagonists
G. Pastorin, C. Bolcato, B. Cacciari, S. Kachler, K. Klotz, C. Montopoli, S. Moro, and G. Spalluto. Farmaco, 60 (8): 643-51 (August 2005)Pastorin, G Bolcato, C Cacciari, B Kachler, S Klotz, K-N Montopoli, C Moro, S Spalluto, G Research Support, Non-U.S. Gov't France Farmaco (Societa chimica italiana : 1989) Farmaco. 2005 Aug;60(8):643-51..
15 years ago by @pharmawuerz
show all tags
Binding
Structure,
Secondary
&
Sites
A3/*antagonists
A2A/antagonists
Rats
*Purines/chemical
Protein
Evaluation,
Receptor
Relationship
Models,
Structure-Activity
Adenosine
Conformation
inhibitors
A1/antagonists
Humans
Molecular
Design
A2B/antagonists
Preclinical
synthesis/chemistry/pharmacology
*Drug
Structure
Drug
BindingStructure,Secondary&SitesA3/*antagonistsA2A/antagonistsRats*Purines/chemicalProteinEvaluation,ReceptorRelationshipModels,Structure-ActivityAdenosineConformationinhibitorsA1/antagonistsHumansMolecularDesignA2B/antagonistsPreclinicalsynthesis/chemistry/pharmacology*DrugStructureDrug
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2A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
B. Bruneau, G. Nemer, J. Schmitt, F. Charron, L. Robitaille, S. Caron, D. Conner, M. Gessler, M. Nemer, C. Seidman and 1 other author(s). Cell, 106 (6): 709-21 (September 2001)Bruneau, B G Nemer, G Schmitt, J P Charron, F Robitaille, L Caron, S Conner, D A Gessler, M Nemer, M Seidman, C E Seidman, J G S10 RR14792/RR/NCRR NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. United States Cell Cell. 2001 Sep 21;106(6):709-21..
15 years ago by @pharmawuerz
show all tags
Congenital/*genetics/physiopathology
Rats
Base
Homozygote
Animal
Connexins/genetics
Atrial
Heterozygote
Sheep
Mice
Bone
Disease
Humans
Genetic
Alignment
Homology,
Development
Electrocardiography
Nucleic
Cell
Myocardium/cytology
Aging
Binding
Factor/*genetics
Sites
Data
Sequence
Knockout
Proteins/deficiency/*genetics
Syndrome
Animals
Development/genetics/*physiology
Forelimb/abnormalities
Models,
Domain
Differentiation
Heart
Embryonic
Acid
T-Box
Abnormalities,
Natriuretic
Multiple/*genetics
Molecular
Promoter
Fetal
and
Regions,
Defects,
Heart/embryology
Congenital/*genetics/physiopathologyRatsBaseHomozygoteAnimalConnexins/geneticsAtrialHeterozygoteSheepMiceBoneDiseaseHumansGeneticAlignmentHomology,DevelopmentElectrocardiographyNucleicCellMyocardium/cytologyAgingBindingFactor/*geneticsSitesDataSequenceKnockoutProteins/deficiency/*geneticsSyndromeAnimalsDevelopment/genetics/*physiologyForelimb/abnormalitiesModels,DomainDifferentiationHeartEmbryonicAcidT-BoxAbnormalities,NatriureticMultiple/*geneticsMolecularPromoterFetalandRegions,Defects,Heart/embryology
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15'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species
L. Cappellacci, P. Franchetti, P. Vita, R. Petrelli, A. Lavecchia, B. Costa, F. Spinetti, C. Martini, K. Klotz, and M. Grifantini. Bioorg Med Chem, 16 (1): 336-53 (January 2008)Cappellacci, Loredana Franchetti, Palmarisa Vita, Patrizia Petrelli, Riccardo Lavecchia, Antonio Costa, Barbara Spinetti, Francesca Martini, Claudia Klotz, Karl-Norbert Grifantini, Mario Research Support, Non-U.S. Gov't England Bioorganic & medicinal chemistry Bioorg Med Chem. 2008 Jan 1;16(1):336-53. Epub 2007 Sep 22..
15 years ago by @pharmawuerz
show all tags
Binding
Humans
Hydrophobicity
A1/*agonists
Protein
Animals
Swine
Receptor
Molecular
Electricity
Simulation
Carbamates/*chemistry
Relationship
Computer
Models,
Purine
Structure-Activity
Adenosine
Nucleosides/*chemistry/*pharmacology
Static
BindingHumansHydrophobicityA1/*agonistsProteinAnimalsSwineReceptorMolecularElectricitySimulationCarbamates/*chemistryRelationshipComputerModels,PurineStructure-ActivityAdenosineNucleosides/*chemistry/*pharmacologyStatic
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1Anion transport in heart.
J. Hume, D. Duan, M. Collier, J. Yamazaki, and B. Horowitz. Physiol. Rev., 80 (1): 31--81 (January 2000)
17 years ago by @hake
show all tags
p-Trifluoromethoxyphenylhydrazone,
Infusions,
Intravenous,
Ion
Edetic
Acetazolamide,
Transport,
Diphosphates,
Transport
Inbred
Animals,
Acid-Base
Female,
Media,
coli,
Agents,
Transmembrane
Cells,
Blood
Solutions,
Carbonyl
Dose-Response
Concentration,
Capillary
Anions,
AMP,
Relationship,
Anhydrase
Alkalies,
Binding
Escherichia
Channel
Biological
Carbon
Exercise,
Adult,
Cations,
Divalent,
Chickens,
Acids,
Dioxide,
Models,
Conductance
Permeability,
Heart
In
Cardiolipins,
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic
Complex
Triphosphate,
Glycogen,
Expression,
Gene
T,
Drug,
Heart,
Sites,
Equilibrium,
Calcium,
Electric
Size,
Animal,
Humans,
Fibrosis
Glyburide,
Disease
Calcium
C57BL,
Chlorides,
Vitro,
Hypoglycemic
Carrier
Hypotonic
Regulator,
Cardiotonic
Culture
Cell
IV,
Pressure,
Hydrogen-Ion
Cystic
Channels,
Carbonic
Acid,
Chloride
Cattle,
Cyclic
Isoproterenol,
Adenosine
Cyanide
Arsenates,
Blockers,
Hypertension,
Anthranilic
Proteins,
Electron
Antibodies,
Inhibitors,
Rate,
Cultured,
Conductivity,
p-Trifluoromethoxyphenylhydrazone,Infusions,Intravenous,IonEdeticAcetazolamide,Transport,Diphosphates,TransportInbredAnimals,Acid-BaseFemale,Media,coli,Agents,TransmembraneCells,BloodSolutions,CarbonylDose-ResponseConcentration,CapillaryAnions,AMP,Relationship,AnhydraseAlkalies,BindingEscherichiaChannelBiologicalCarbonExercise,Adult,Cations,Divalent,Chickens,Acids,Dioxide,Models,ConductancePermeability,HeartInCardiolipins,4,4'-Diisothiocyanostilbene-2,2'-DisulfonicComplexTriphosphate,Glycogen,Expression,GeneT,Drug,Heart,Sites,Equilibrium,Calcium,ElectricSize,Animal,Humans,FibrosisGlyburide,DiseaseCalciumC57BL,Chlorides,Vitro,HypoglycemicCarrierHypotonicRegulator,CardiotonicCultureCellIV,Pressure,Hydrogen-IonCysticChannels,CarbonicAcid,ChlorideCattle,CyclicIsoproterenol,AdenosineCyanideArsenates,Blockers,Hypertension,AnthranilicProteins,ElectronAntibodies,Inhibitors,Rate,Cultured,Conductivity,
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1Numerical simulation of local calcium movements during L-type calcium channel gating in the cardiac diad.
C. Soeller, and M. Cannell. Biophys. J., 73 (1): 97-111 (July 1997)
17 years ago by @hake
show all tags
Binding
Calcium,
Channel
Ion
Cytosol,
Simulation,
Channels,
Support,
L-Type,
Transduction,
Transport,
Reticulum,
Receptor
Gating,
Membrane,
Models,
Structural,
Ryanodine
9199775
Calcium
Myocardium,
Cardiovascular,
Sarcoplasmic
Gov't,
Research
Time
Factors,
Kinetics,
Proteins,
Non-U.S.
Channel,
Mathematics,
Computer
Sarcolemma,
Muscle
Signal
Cell
Heart,
Release
Sites,
BindingCalcium,ChannelIonCytosol,Simulation,Channels,Support,L-Type,Transduction,Transport,Reticulum,ReceptorGating,Membrane,Models,Structural,Ryanodine9199775CalciumMyocardium,Cardiovascular,SarcoplasmicGov't,ResearchTimeFactors,Kinetics,Proteins,Non-U.S.Channel,Mathematics,ComputerSarcolemma,MuscleSignalCellHeart,ReleaseSites,
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1Critical determinants of Ca$^2+$-dependent inactivation within an EF-hand motif of L-type Ca$^2+$ channels.
B. Peterson, J. Lee, J. Mulle, Y. Wang, M. de Leon, and D. Yue. Biophys. J., 78 (4): 1906--1920 (April 2000)
17 years ago by @hake
show all tags
Binding
Biophysics,
Structure,
Calcium,
Biological,
Channels,
Mutagenesis,
Sequence
Potentials,
Support,
L-Type,
Consensus
Protein
Humans,
P.H.S.,
Line,
Sequence,
Models,
10733970
Feedback,
Acid
Calcium
Site-Directed,
Gov't,
Research
Secondary,
Data,
Calmodulin,
Molecular
Proteins,
U.S.
Membrane
Motifs,
Amino
Recombinant
Cell
Sites,
BindingBiophysics,Structure,Calcium,Biological,Channels,Mutagenesis,SequencePotentials,Support,L-Type,ConsensusProteinHumans,P.H.S.,Line,Sequence,Models,10733970Feedback,AcidCalciumSite-Directed,Gov't,ResearchSecondary,Data,Calmodulin,MolecularProteins,U.S.MembraneMotifs,AminoRecombinantCellSites,
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publications (hide)9
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1Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro 1,2,4-triazolo 3,4-f-purines as potential adenosine receptor antagonists

1Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites

1The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: application to a lead optimization of a human A3 adenosine receptor antagonist

1Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro 1,2,4-triazolo 3,4-f-purines as adenosine receptor antagonists

2A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

15'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species

1Anion transport in heart.

1Numerical simulation of local calcium movements during L-type calcium channel gating in the cardiac diad.

1Critical determinants of Ca$^2+$-dependent inactivation within an EF-hand motif of L-type Ca$^2+$ channels.

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publications (hide)9 displayallpublications onlypublications per page5102050100 sort byadded attitleauthorpublication dateentry typehelp for advanced sorting... RSSBibTeXRDFmore...

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publications (hide)9
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