Аннотация
We present a minimal mathematical model of Ca(2+) spark triggering
under voltage-clamp conditions in ventricular myocytes. The model
predicts changes in excitation-contraction coupling 'gain' that result
from diverse experimental interventions. We compare model results
to several sets of data, and, in so doing, place apparent constraints
on physiologically relevant model parameters. Specifically, the analysis
suggests that many L-type Ca(2+) channel openings can potentially
trigger each Ca(2+) spark, but the probability that an individual
opening will trigger a spark is low. This procedure helps to reconcile
contradictory results obtained in recent studies; moreover, this
new model should be a useful tool for understanding changes in gain
that occur physiologically and in disease.
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