%0 Journal Article %1 Reddington1989 %A Reddington, M. %A Klotz, K. N. %A Lohse, M. J. %A Hietel, B. %D 1989 %J FEBS Lett %K Adenosine/*metabolism Animals Brain/*metabolism Guanine Nucleotides/*pharmacology Purinergic/drug Rats Xanthines/*pharmacology effects effects/*radiation Receptor %N 1-2 %P 125-8 %T Radiation inactivation analysis of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation size in the presence of guanine nucleotide %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2759228 %V 252 %X Radiation inactivation analysis of the binding of the A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes yielded a radiation inactivation size of 58 kDa. In the presence of GTP gamma S this was reduced to 33 kDa, in good agreement with the size of the ligand-binding subunit detected after photoaffinity labelling. The data indicate that the structural association of A1 adenosine receptors with G-protein components is altered in situ in the presence of guanine nucleotides.

@article{Reddington1989, abstract = {Radiation inactivation analysis of the binding of the A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes yielded a radiation inactivation size of 58 kDa. In the presence of GTP gamma S this was reduced to 33 kDa, in good agreement with the size of the ligand-binding subunit detected after photoaffinity labelling. The data indicate that the structural association of A1 adenosine receptors with G-protein components is altered in situ in the presence of guanine nucleotides.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Reddington, M. and Klotz, K. N. and Lohse, M. J. and Hietel, B.}, biburl = {https://www.bibsonomy.org/bibtex/2bc70bddea24361a2bb788cea794932cf/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {08d16726cf4741adbbe31dd80404b253}, intrahash = {bc70bddea24361a2bb788cea794932cf}, issn = {0014-5793 (Print) 0014-5793 (Linking)}, journal = {FEBS Lett}, keywords = {Adenosine/*metabolism Animals Brain/*metabolism Guanine Nucleotides/*pharmacology Purinergic/drug Rats Xanthines/*pharmacology effects effects/*radiation Receptor}, month = {Jul 31}, note = {Reddington, M Klotz, K N Lohse, M J Hietel, B Research Support, Non-U.S. Gov't Netherlands FEBS letters FEBS Lett. 1989 Jul 31;252(1-2):125-8.}, number = {1-2}, pages = {125-8}, shorttitle = {Radiation inactivation analysis of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation size in the presence of guanine nucleotide}, timestamp = {2010-12-14T18:20:08.000+0100}, title = {Radiation inactivation analysis of the A1 adenosine receptor of rat brain. Decrease in radiation inactivation size in the presence of guanine nucleotide}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2759228}, volume = 252, year = 1989 }