Abstract
Radiation inactivation analysis of the binding of the A1 adenosine
receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine to rat brain
membranes yielded a radiation inactivation size of 58 kDa. In the
presence of GTP gamma S this was reduced to 33 kDa, in good agreement
with the size of the ligand-binding subunit detected after photoaffinity
labelling. The data indicate that the structural association of A1
adenosine receptors with G-protein components is altered in situ
in the presence of guanine nucleotides.
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