Abstract
The aim of this study was to develop the Mayo Dysphagia Questionnaire-30
Day (MDQ-30), a tool to measure esophageal dysphagia, by adapting
items from validated instruments for use in clinical trials, and
assess its feasibility, reproducibility, and concurrent validity.
Outpatients referred to endoscopy for dysphagia or seen in a specialty
clinic were recruited. Feasibility testing was done to identify problematic
items. Reproducibility was measured by test-retest format. Concurrent
validity reflects agreement between information gathered in a structured
interview versus the patients' written responses. The MDQ-30, a 28-item
instrument, took 10 min (range = 5-30 min) to complete. Four hundred
thirty-one outpatients 210 (49%) men; mean age = 61 years participated.
Overall, most concurrent validity kappa values for dysphagia were
very good to excellent with a median of 0.78 (min 0.28, max 0.95).
The majority of reproducibility kappa values for dysphagia were moderate
to excellent with a median kappa value of 0.66 (min 0.07, max 1.0).
Overall, concurrent validity and reproducibility kappa values for
gastroesophageal reflux disease (GERD) symptoms were 0.81 (95% CI
= 0.72, 0.91) and 0.66 (95% CI = 0.55, 0.77), respectively. Individual
item percent agreement was generally very good to excellent. Internal
consistency was excellent. We conclude that the MDQ-30 is an easy-to-complete
tool to evaluate reliably dysphagia symptoms over the last 30 days.
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