%0 Journal Article %1 yingsakmongkol2021effect %A Yingsakmongkol, Narongchai %A Tanunyutthawongse, Chantra %A Flemmig, Joerg %A Kuehne, Friedrich-Wilhelm %D 2021 %J Journal of Diabetes and Treatment (ISSN: 2574-7568) %K Chloritebaseddrug Diabetesmellitus DiabeticFootUlcer HbA1c Neutrophillymphocyteratio Redbloodcelldistributionwidth WF10 Woundhealing %N 1 %P 1-12 %R https://doi.org/10.29011/2574-7568.001086 %T Effect of the Chlorite-Based Drug WF10 on Hemoglobin A1c, Hematological Biomarkers in Uncontrolled Diabetic Patients with Foot Ulcer %U https://www.gavinpublishers.com/article/view/effect-of-the-chlorite-based-drug-wf10-on-hemoglobin-a1c-hematological-biomarkers-in-uncontrolled-diabetic-patients-with-foot-ulcer %V 6 %X Aims: To evaluate degree and kinetics of WF10 effects on HbA1c, associated hematological biomarkers, and wound healing in uncontrolled T2DM patients with DFU. Methods: In this prospective, interventional, pretest-posttest study, 40 DFU patients with HbA1c > 8.5 % were treated with standard therapy plus five weekly infusions of the chlorite-based drug WF10 within outpatient department. Besides HbA1c kinetics, we studied red blood cell distribution width (RDW-CV) value, neutrophil-lymphocyte ratio (NLR) and wound healing at week (W) 0, 4, 8 and 12. Results: In 38 PP-treated patients WF10 decreased HbA1c value from 10.48 % at baseline (BL) to 8.06 % at W8 and Wound Severity Score (WSS) from 8.0 to 1.4 (both p < 0.0001) at W12. RDW-CV was diminished from 13.5 % to 12.8 % (p = 0.0021), NLR decreased from 2.8 to 2.2 (NS) but significantly decreased in patients with NLR > 3.5 at BL, from 6.3 to 3.2. No serious side effect of WF10 was observed. Conclusion: Standard therapy of DFU plus adjunct WF10 application consistently and long-lastingly decreased high HbA1c values and showed good outcome of wound healing in patients with uncontrolled diabetes. The used treatment protocol is applicable for outpatient treatment

@article{yingsakmongkol2021effect, abstract = {Aims: To evaluate degree and kinetics of WF10 effects on HbA1c, associated hematological biomarkers, and wound healing in uncontrolled T2DM patients with DFU. Methods: In this prospective, interventional, pretest-posttest study, 40 DFU patients with HbA1c > 8.5 % were treated with standard therapy plus five weekly infusions of the chlorite-based drug WF10 within outpatient department. Besides HbA1c kinetics, we studied red blood cell distribution width (RDW-CV) value, neutrophil-lymphocyte ratio (NLR) and wound healing at week (W) 0, 4, 8 and 12. Results: In 38 PP-treated patients WF10 decreased HbA1c value from 10.48 % at baseline (BL) to 8.06 % at W8 and Wound Severity Score (WSS) from 8.0 to 1.4 (both p < 0.0001) at W12. RDW-CV was diminished from 13.5 % to 12.8 % (p = 0.0021), NLR decreased from 2.8 to 2.2 (NS) but significantly decreased in patients with NLR > 3.5 at BL, from 6.3 to 3.2. No serious side effect of WF10 was observed. Conclusion: Standard therapy of DFU plus adjunct WF10 application consistently and long-lastingly decreased high HbA1c values and showed good outcome of wound healing in patients with uncontrolled diabetes. The used treatment protocol is applicable for outpatient treatment}, added-at = {2021-02-19T06:17:50.000+0100}, author = {Yingsakmongkol, Narongchai and Tanunyutthawongse, Chantra and Flemmig, Joerg and Kuehne, Friedrich-Wilhelm}, biburl = {https://www.bibsonomy.org/bibtex/25581ad85bee3d67d1b8a66d4ea4ffe7b/alyssacarter}, doi = {https://doi.org/10.29011/2574-7568.001086}, interhash = {0d0fddac177e716cc20a38e92c49d49e}, intrahash = {5581ad85bee3d67d1b8a66d4ea4ffe7b}, issn = {2574-7568}, journal = {Journal of Diabetes and Treatment (ISSN: 2574-7568)}, keywords = {Chloritebaseddrug Diabetesmellitus DiabeticFootUlcer HbA1c Neutrophillymphocyteratio Redbloodcelldistributionwidth WF10 Woundhealing}, language = {english}, month = {February}, number = 1, pages = {1-12}, timestamp = {2021-10-09T12:40:38.000+0200}, title = {Effect of the Chlorite-Based Drug WF10 on Hemoglobin A1c, Hematological Biomarkers in Uncontrolled Diabetic Patients with Foot Ulcer}, url = {https://www.gavinpublishers.com/article/view/effect-of-the-chlorite-based-drug-wf10-on-hemoglobin-a1c-hematological-biomarkers-in-uncontrolled-diabetic-patients-with-foot-ulcer}, volume = 6, year = 2021 }