Аннотация
A Monte Carlo method for modeling the neuromuscular junction is described
in which the three-dimensional structure of the synapse can be specified.
Complexities can be introduced into the acetylcholine kinetic model
used with only a small increase in computing time. The Monte Carlo
technique is shown to be superior to differential equation modeling
methods (although less accurate) if a three-dimensional representation
of synaptic geometry is desired. The conceptual development of the
model is presented and the accuracy estimated. The consequences of
manipulations such as varying the spacing of secondary synaptic folds
or that between the release of multiple quantal packets of acetylcholine,
are also presented. Increasing the spacing between folds increases
peak current. Decreased spacing of adjacent quantal release sites
increases the potentiation of peak current.
- 1873466
- acetylcholine,
- algorithms,
- animals,
- anura,
- biophysics,
- carlo
- cholinergic,
- computer
- cs,
- electron,
- electrophysiology,
- endplate,
- gov't,
- junction,
- kineti,
- method,
- microscopy,
- models,
- monte
- motor
- neurological,
- neuromuscular
- p.h.s.,
- receptors,
- research
- simulation,
- support,
- u.s.
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