%0 Journal Article %1 Lavenu:2006:Epidemiol-Infect:16316493 %A Lavenu, A %A Leruez-Ville, M %A Chaix, M L %A Boelle, P Y %A Rogez, S %A Freymuth, F %A Hay, A %A Rouzioux, C %A Carrat, F %D 2006 %J Epidemiol Infect %K epi evolution imported influenza %N 3 %P 514-520 %R 10.1017/S0950268805005686 %T Detailed analysis of the genetic evolution of influenza virus during the course of an epidemic %U http://www.ncbi.nlm.nih.gov/pubmed/16316493 %V 134 %X The genetic variability of influenza virus is usually studied with sequences selected over numerous years and countries, and rarely within a single season. Here we examined the viral evolution and the correlation between genetic and clinical features during an epidemic. From a French prospective household-based study in 1999-2000, 99 infected patients were randomly selected. The HA1 genomic domain was sequenced. Phylogenetic analysis showed the existence of two groups of A/H3N2 viruses. We found no distinct pattern of genomic evolution within either group according to time. A spatial correlation with the nucleotide distances was shown. The average nucleotide diversity was 3.4x10-3 nucleotides per site, and did not differ between the groups. A lower number of segregating sites was observed in patients who experienced influenza-like symptoms during the previous epidemic. These results suggest that the influenza virus undergoes regular HA1 nucleotide changes, but without clonal expansion of mutant strains within a single epidemic.

@article{Lavenu:2006:Epidemiol-Infect:16316493, abstract = {The genetic variability of influenza virus is usually studied with sequences selected over numerous years and countries, and rarely within a single season. Here we examined the viral evolution and the correlation between genetic and clinical features during an epidemic. From a French prospective household-based study in 1999-2000, 99 infected patients were randomly selected. The HA1 genomic domain was sequenced. Phylogenetic analysis showed the existence of two groups of A/H3N2 viruses. We found no distinct pattern of genomic evolution within either group according to time. A spatial correlation with the nucleotide distances was shown. The average nucleotide diversity was 3.4x10-3 nucleotides per site, and did not differ between the groups. A lower number of segregating sites was observed in patients who experienced influenza-like symptoms during the previous epidemic. These results suggest that the influenza virus undergoes regular HA1 nucleotide changes, but without clonal expansion of mutant strains within a single epidemic.}, added-at = {2009-07-21T00:06:38.000+0200}, author = {Lavenu, A and Leruez-Ville, M and Chaix, M L and Boelle, P Y and Rogez, S and Freymuth, F and Hay, A and Rouzioux, C and Carrat, F}, biburl = {https://www.bibsonomy.org/bibtex/26cc535f223b204c13cb6eaf40a4896bf/ebo}, description = {Detailed analysis of the genetic evolution of infl...[Epidemiol Infect. 2006] - PubMed Result}, doi = {10.1017/S0950268805005686}, interhash = {0d7334fc99524e077cab98de2ace34d1}, intrahash = {6cc535f223b204c13cb6eaf40a4896bf}, journal = {Epidemiol Infect}, keywords = {epi evolution imported influenza}, month = Jun, number = 3, pages = {514-520}, pmid = {16316493}, timestamp = {2009-07-21T00:06:38.000+0200}, title = {Detailed analysis of the genetic evolution of influenza virus during the course of an epidemic}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16316493}, volume = 134, year = 2006 }