%0 Journal Article %1 citeulike:500611 %A Herold, K. %A Gollmick, F. A. %A Groth, I. %A Roth, M. %A Menzel, K. D. %A Möllmann, U. %A Gräfe, U. %A Hertweck, C. %C Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany. %D 2005 %J Chemistry %K pks biosynthesis %N 19 %P 5523--5530 %R 10.1002/chem.200500320 %T Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance. %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15940739 %V 11 %X Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.

@article{citeulike:500611, abstract = {Cervimycins A-D are novel polyketide glycosides with significant activity against multi-drug-resistant staphylococci and vancomycin-resistant enterococci. They are produced by a strain of Streptomyces tendae, isolated from an ancient cave. The structures of the cervimycins were determined by performing extensive NMR and chemical degradation studies. All cervimycins have a common tetracyclic polyketide core that is substituted with unusual di- and tetrasaccharide chains, composed exclusively of trideoxysugars; however, they differ in the acetyl and carbamoyl ring substituent and in the highly unusual terminal methylmalonyl and dimethylmalonyl residues.}, added-at = {2007-02-02T11:55:53.000+0100}, address = {Leibniz Institute for Natural Products Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.}, author = {Herold, K. and Gollmick, F. A. and Groth, I. and Roth, M. and Menzel, K. D. and Möllmann, U. and Gräfe, U. and Hertweck, C.}, biburl = {https://www.bibsonomy.org/bibtex/286d284b89a23deb7e282a6207d98d0a2/robert}, citeulike-article-id = {500611}, doi = {10.1002/chem.200500320}, interhash = {070461eca24a5ce727052dcec5cf6905}, intrahash = {86d284b89a23deb7e282a6207d98d0a2}, issn = {0947-6539}, journal = {Chemistry}, keywords = {pks biosynthesis}, month = {September}, number = 19, pages = {5523--5530}, priority = {2}, timestamp = {2007-02-02T11:55:53.000+0100}, title = {Cervimycin A-D: a polyketide glycoside complex from a cave bacterium can defeat vancomycin resistance.}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=pubmed\&dopt=Abstract\&list_uids=15940739}, volume = 11, year = 2005 }