%0 Journal Article %1 Gandal:2018:Science:29439242 %A Gandal, M J %A Haney, J R %A Parikshak, N N %A Leppa, V %A Ramaswami, G %A Hartl, C %A Schork, A J %A Appadurai, V %A Buil, A %A Werge, T M %A Liu, C %A White, K P %A CommonMind Consortium, %A PsychENCODE Consortium, %A iPSYCH-BROAD Working Group, %A Horvath, S %A Geschwind, D H %D 2018 %J Science %K astrocyte brain neurology neuropathology paywall %N 6376 %P 693-697 %R 10.1126/science.aad6469 %T Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap %U https://www.ncbi.nlm.nih.gov/pubmed/29439242 %V 359 %X The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism-based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity.

@article{Gandal:2018:Science:29439242, abstract = {The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism-based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity.}, added-at = {2018-02-15T00:11:26.000+0100}, author = {Gandal, M J and Haney, J R and Parikshak, N N and Leppa, V and Ramaswami, G and Hartl, C and Schork, A J and Appadurai, V and Buil, A and Werge, T M and Liu, C and White, K P and {CommonMind Consortium} and {PsychENCODE Consortium} and {iPSYCH-BROAD Working Group} and Horvath, S and Geschwind, D H}, biburl = {https://www.bibsonomy.org/bibtex/224918a89b3fd439c8c1249a7570d48a1/marcsaric}, description = {Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. - PubMed - NCBI}, doi = {10.1126/science.aad6469}, interhash = {07afb00d55bb414f3457191f1cfff925}, intrahash = {24918a89b3fd439c8c1249a7570d48a1}, journal = {Science}, keywords = {astrocyte brain neurology neuropathology paywall}, month = feb, number = 6376, pages = {693-697}, pmid = {29439242}, timestamp = {2018-02-15T00:11:26.000+0100}, title = {Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap}, url = {https://www.ncbi.nlm.nih.gov/pubmed/29439242}, volume = 359, year = 2018 }