%0 Journal Article %1 Ali2011 %A Ali, Hasrat %A Ait-Mohand, Samia %A Gosselin, Simon %A van Lier, Johan E %A Guérin, Brigitte %D 2011 %J J Org Chem %K chemistry/diagnosticuse;Positron-EmissionTomography chemistry;Peptides chemistry;Palladium Catalysis;Indoles %N 6 %P 1887--1890 %R 10.1021/jo102083g %T Phthalocyanine-peptide conjugates via palladium-catalyzed cross-coupling reactions. %U http://dx.doi.org/10.1021/jo102083g %V 76 %X Phthalocyanines (Pc) were conjugated with peptide moieties to improve their target selectivity for potential use as fluorescence and/or positron emission tomography (PET) probes in medical imaging. Three synthetic methods based on palladium-catalyzed cross-coupling reactions (Sonogashira, Buchwald-Hartwig, and Suzuki-Miyaura) were investigated. Using these methods, a series of peptides monofunctionalized with Pc at the N/C-terminal position or on a phenylalanine side chain was obtained in good yields and characterized.

@article{Ali2011, abstract = {Phthalocyanines (Pc) were conjugated with peptide moieties to improve their target selectivity for potential use as fluorescence and/or positron emission tomography (PET) probes in medical imaging. Three synthetic methods based on palladium-catalyzed cross-coupling reactions (Sonogashira, Buchwald-Hartwig, and Suzuki-Miyaura) were investigated. Using these methods, a series of peptides monofunctionalized with Pc at the N/C-terminal position or on a phenylalanine side chain was obtained in good yields and characterized.}, added-at = {2011-08-01T19:46:36.000+0200}, author = {Ali, Hasrat and Ait-Mohand, Samia and Gosselin, Simon and van Lier, Johan E and Guérin, Brigitte}, biburl = {https://www.bibsonomy.org/bibtex/25e49f52049037b4a105a955dfcf56129/crc_chus}, doi = {10.1021/jo102083g}, institution = {Centre d'imagerie moléculaire de Sherbrooke (CIMS), Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec, Canada J1H 5N4.}, interhash = {125b5ee726baed45cf932742a1b5b184}, intrahash = {5e49f52049037b4a105a955dfcf56129}, journal = {J Org Chem}, keywords = {chemistry/diagnosticuse;Positron-EmissionTomography chemistry;Peptides chemistry;Palladium Catalysis;Indoles}, language = {eng}, medline-pst = {ppublish}, month = Mar, number = 6, pages = {1887--1890}, pmid = {21302913}, timestamp = {2011-08-01T19:46:36.000+0200}, title = {Phthalocyanine-peptide conjugates via palladium-catalyzed cross-coupling reactions.}, url = {http://dx.doi.org/10.1021/jo102083g}, volume = 76, year = 2011 }