Abstract
Schiff base N,N'-bis(salicylidene)-1,2-phenylenediamine, salophen, is a
substance that presents synergism when combined with amikacin against
Staphylococcus aureus and Escherichia coli. Measurements of temperature
dependence of the Raman spectra of salophen combined with thermal
analysis investigations are presented. The room temperature crystalline
structure seems to be stable up to the temperature where the phase
transition from solid to liquid (433-443 K) is observed. The Raman
spectra in the temperature range 433-443 K were observed to be
characterized by the loss of external vibrational modes, in accordance
with thermal analysis curves. According to thermogravimetric analysis,
salophen shows a weight loss variation in the temperature range 300-453
K corresponding to 5% loss in weight, which is attributed to
dehydration and materials melting temperature. The enthalpy (Delta H)
obtained from the integration of the differential scanning calorimetry peak at melting (T-m = 438 K) and decomposition temperature (T-d = 484
K) is founded to be -91 J/g and 239 J/g, respectively. Finally, it was
carried out biological assays to evaluate the antibacterial potential of
the salophen. (C) 2016 Elsevier B.V. All rights reserved.
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