Аннотация
Chemical genetics has arisen as a tool for the discovery of pathways
and proteins in mammalian systems. This approach, comprising small-molecule
screening combined with biochemical and genomic target identification
methods, enables one to assess which proteins are involved in regulating
a particular phenotype. Applied to cell death, this strategy can
reveal novel targets and pathways regulating the demise of mammalian
cells. Numerous diseases have been linked to the loss of regulation
of cell death. Defining the mechanisms governing cell death in these
diseases might lead to the discovery of therapeutic agents and targets
and provide a richer understanding of the mortality of living systems.
Recent advances include the discovery of novel small molecules regulating
cell death pathways -- necrostatin and erastin -- as well as
the elucidation of the mechanism of death induced in cancer cells
by the cytotoxic agent Apratoxin A.
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