%0 Journal Article %1 WOS:000232238900005 %A Polla, GI %A Vega, DR %A Lanza, H %A Tombari, DG %A Baggio, R %A Ayala, AP %A Mendes, J %A Fernandez, D %A Leyva, G %A Dartayet, G %C RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS %D 2005 %I ELSEVIER %J INTERNATIONAL JOURNAL OF PHARMACEUTICS %K polymorphism; stability} {olanzapine; %N 1-2 %P 33-40 %R 10.1016/j.ijpharm.2005.05.035 %T Thermal behaviour and stability in Olanzapine %V 301 %X The stability and thermal behaviour of two anhydrate phases and a new mixed water:DMSO solvate of Olanzapine (2-methyl4-(4-methyl-1-piperazinyl)-10H-thieno-2,3-b1,5benzodiaz epine) are studied by different methods: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and Raman scattering (RS). Single crystal structural data for the latter phase are presented, confirming the presence of the (Olanzapine)(2) dimer as the structural building unit of all known phases of the drug, either anhydrate or solvated. An apparent interconversion between both solid state forms is shown to be an artifact and explained in terms of a melting-recrystallization process. (C) 2005 Elsevier B.V All rights reserved.

@article{WOS:000232238900005, abstract = {The stability and thermal behaviour of two anhydrate phases and a new mixed water:DMSO solvate of Olanzapine (2-methyl4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b][1,5]benzodiaz epine) are studied by different methods: differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and Raman scattering (RS). Single crystal structural data for the latter phase are presented, confirming the presence of the (Olanzapine)(2) dimer as the structural building unit of all known phases of the drug, either anhydrate or solvated. An apparent interconversion between both solid state forms is shown to be an artifact and explained in terms of a melting-recrystallization process. (C) 2005 Elsevier B.V All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS}, author = {Polla, GI and Vega, DR and Lanza, H and Tombari, DG and Baggio, R and Ayala, AP and Mendes, J and Fernandez, D and Leyva, G and Dartayet, G}, biburl = {https://www.bibsonomy.org/bibtex/27e5700e532533c859ad136e1b8040138/ppgfis_ufc_br}, doi = {10.1016/j.ijpharm.2005.05.035}, interhash = {27a101f77c7d93067b70b9735256e996}, intrahash = {7e5700e532533c859ad136e1b8040138}, issn = {0378-5173}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, keywords = {polymorphism; stability} {olanzapine;}, number = {1-2}, pages = {33-40}, publisher = {ELSEVIER}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Thermal behaviour and stability in Olanzapine}, tppubtype = {article}, volume = 301, year = 2005 }