%0 Journal Article %1 mateus2020selective %A Mateus, Jose %A Grifoni, Alba %A Tarke, Alison %A Sidney, John %A Ramirez, Sydney I. %A Dan, Jennifer M. %A Burger, Zoe C. %A Rawlings, Stephen A. %A Smith, Davey M. %A Phillips, Elizabeth %A Mallal, Simon %A Lammers, Marshall %A Rubiro, Paul %A Quiambao, Lorenzo %A Sutherland, Aaron %A Yu, Esther Dawen %A da Silva Antunes, Ricardo %A Greenbaum, Jason %A Frazier, April %A Markmann, Alena J. %A Premkumar, Lakshmanane %A de Silva, Aravinda %A Peters, Bjoern %A Crotty, Shane %A Sette, Alessandro %A Weiskopf, Daniela %D 2020 %I American Association for the Advancement of Science %J Science %K T_cell covid-19 %R 10.1126/science.abd3871 %T Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans %U https://science.sciencemag.org/content/early/2020/08/04/science.abd3871 %X Many unknowns exist about human immune responses to the SARS-CoV-2 virus. SARS-CoV-2 reactive CD4+ T cells have been reported in unexposed individuals, suggesting pre-existing cross-reactive T cell memory in 20-50\% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4+ T cell repertoire. We demonstrate a range of pre-existing memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63, or HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in COVID-19 disease.

@article{mateus2020selective, abstract = {Many unknowns exist about human immune responses to the SARS-CoV-2 virus. SARS-CoV-2 reactive CD4+ T cells have been reported in unexposed individuals, suggesting pre-existing cross-reactive T cell memory in 20-50\% of people. However, the source of those T cells has been speculative. Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4+ T cell repertoire. We demonstrate a range of pre-existing memory CD4+ T cells that are cross-reactive with comparable affinity to SARS-CoV-2 and the common cold coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63, or HCoV-HKU1. Thus, variegated T cell memory to coronaviruses that cause the common cold may underlie at least some of the extensive heterogeneity observed in COVID-19 disease.}, added-at = {2020-09-16T17:21:19.000+0200}, author = {Mateus, Jose and Grifoni, Alba and Tarke, Alison and Sidney, John and Ramirez, Sydney I. and Dan, Jennifer M. and Burger, Zoe C. and Rawlings, Stephen A. and Smith, Davey M. and Phillips, Elizabeth and Mallal, Simon and Lammers, Marshall and Rubiro, Paul and Quiambao, Lorenzo and Sutherland, Aaron and Yu, Esther Dawen and da Silva Antunes, Ricardo and Greenbaum, Jason and Frazier, April and Markmann, Alena J. and Premkumar, Lakshmanane and de Silva, Aravinda and Peters, Bjoern and Crotty, Shane and Sette, Alessandro and Weiskopf, Daniela}, biburl = {https://www.bibsonomy.org/bibtex/2eb723069f6ced450ca15ce23ef7f0d77/fordham1}, description = {Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans | Science}, doi = {10.1126/science.abd3871}, elocation-id = {eabd3871}, eprint = {https://science.sciencemag.org/content/early/2020/08/04/science.abd3871.full.pdf}, interhash = {2e747e7f440283dac32ce69d56a0ea17}, intrahash = {eb723069f6ced450ca15ce23ef7f0d77}, issn = {0036-8075}, journal = {Science}, keywords = {T_cell covid-19}, publisher = {American Association for the Advancement of Science}, timestamp = {2020-09-16T17:21:19.000+0200}, title = {Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans}, url = {https://science.sciencemag.org/content/early/2020/08/04/science.abd3871}, year = 2020 }