Traditional textbook representations of the prokaryotic cytoplasm
show an amorphous, unstructured amalgamation of proteins and small
molecules in which a randomly arranged chromosome resides. The development
and application of a swathe of microscopic techniques over the last
10 years in particular, has shown this image of the microbial cell
to be incorrect: the cytoplasm is highly structured with many proteins
carrying out their assigned functions at specific subcellular locations;
bacteria contain cytoskeletal elements including microtubule, actin
and intermediate filament homologues; the chromosome is not randomly
folded and is organized in such a way as to facilitate efficient
segregation upon cell division. This review will concentrate on recent
advances in our understanding of subcellular architecture and the
techniques that have led to these discoveries.
%0 Journal Article
%1 Lewi_2004_1135
%A Lewis, Peter J
%D 2004
%J Mol. Microbiol.
%K 15554957 Bacteria, Bacterial, Chromosomes, Cytoplasm, Cytoskeleton, Gov't, Macromolecular Microscopy, Non-U.S. Research Substances, Support,
%N 5
%P 1135--1150
%R 10.1111/j.1365-2958.2004.04343.x
%T Bacterial subcellular architecture: recent advances and future prospects.
%U http://dx.doi.org/10.1111/j.1365-2958.2004.04343.x
%V 54
%X Traditional textbook representations of the prokaryotic cytoplasm
show an amorphous, unstructured amalgamation of proteins and small
molecules in which a randomly arranged chromosome resides. The development
and application of a swathe of microscopic techniques over the last
10 years in particular, has shown this image of the microbial cell
to be incorrect: the cytoplasm is highly structured with many proteins
carrying out their assigned functions at specific subcellular locations;
bacteria contain cytoskeletal elements including microtubule, actin
and intermediate filament homologues; the chromosome is not randomly
folded and is organized in such a way as to facilitate efficient
segregation upon cell division. This review will concentrate on recent
advances in our understanding of subcellular architecture and the
techniques that have led to these discoveries.
@article{Lewi_2004_1135,
abstract = {Traditional textbook representations of the prokaryotic cytoplasm
show an amorphous, unstructured amalgamation of proteins and small
molecules in which a randomly arranged chromosome resides. The development
and application of a swathe of microscopic techniques over the last
10 years in particular, has shown this image of the microbial cell
to be incorrect: the cytoplasm is highly structured with many proteins
carrying out their assigned functions at specific subcellular locations;
bacteria contain cytoskeletal elements including microtubule, actin
and intermediate filament homologues; the chromosome is not randomly
folded and is organized in such a way as to facilitate efficient
segregation upon cell division. This review will concentrate on recent
advances in our understanding of subcellular architecture and the
techniques that have led to these discoveries.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Lewis, Peter J},
biburl = {https://www.bibsonomy.org/bibtex/278c286864df1fe320f71913ca47e7e84/hake},
description = {The whole bibliography file I use.},
doi = {10.1111/j.1365-2958.2004.04343.x},
file = {Lewi_2004_1135.pdf:Lewi_2004_1135.pdf:PDF},
interhash = {3232165a87c68ef26f25bc7169a52884},
intrahash = {78c286864df1fe320f71913ca47e7e84},
journal = {Mol. Microbiol.},
keywords = {15554957 Bacteria, Bacterial, Chromosomes, Cytoplasm, Cytoskeleton, Gov't, Macromolecular Microscopy, Non-U.S. Research Substances, Support,},
month = Dec,
number = 5,
pages = {1135--1150},
pii = {MMI4343},
pmid = {15554957},
timestamp = {2009-06-03T11:21:19.000+0200},
title = {Bacterial subcellular architecture: recent advances and future prospects.},
url = {http://dx.doi.org/10.1111/j.1365-2958.2004.04343.x},
volume = 54,
year = 2004
}