%0 Journal Article %1 Nguyen2013 %A Nguyen, Nguyet Minh %A Thi Hue Kien, Duong %A Tuan, Trung Vu %A Quyen, Nguyen Than Ha %A Tran, Chau N B. %A Vo Thi, Long %A Thi, Dui Le %A Nguyen, Hoa Lan %A Farrar, Jeremy J. %A Holmes, Edward C. %A Rabaa, Maia A. %A Bryant, Juliet E. %A Nguyen, Truong Thanh %A Nguyen, Huong Thi Cam %A Nguyen, Lan Thi Hong %A Pham, Mai Phuong %A Nguyen, Hung The %A Luong, Tai Thi Hue %A Wills, Bridget %A Nguyen, Chau Van Vinh %A Wolbers, Marcel %A Simmons, Cameron P. %D 2013 %J Proc Natl Acad Sci U S A %K dengue virus transmission mosquito %N 22 %P 9072--9077 %R 10.1073/pnas.1303395110 %T Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes. %U http://dx.doi.org/10.1073/pnas.1303395110 %V 110 %X Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50\% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.

@article{Nguyen2013, abstract = {Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50\% mosquito infectious dose for each of DENV-1-4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.}, added-at = {2013-06-08T02:11:42.000+0200}, author = {Nguyen, Nguyet Minh and {Thi Hue Kien}, Duong and Tuan, Trung Vu and Quyen, Nguyen Than Ha and Tran, Chau N B. and {Vo Thi}, Long and Thi, Dui Le and Nguyen, Hoa Lan and Farrar, Jeremy J. and Holmes, Edward C. and Rabaa, Maia A. and Bryant, Juliet E. and Nguyen, Truong Thanh and Nguyen, Huong Thi Cam and Nguyen, Lan Thi Hong and Pham, Mai Phuong and Nguyen, Hung The and Luong, Tai Thi Hue and Wills, Bridget and Nguyen, Chau Van Vinh and Wolbers, Marcel and Simmons, Cameron P.}, biburl = {https://www.bibsonomy.org/bibtex/295ded46dda9b4db0740bdb52259c9c97/aorchid}, description = {clinical and virologic factors associated with transmission of dengue. Surprised this was not already done and surprised it is in PNASU.}, doi = {10.1073/pnas.1303395110}, file = {:ID_General/Virus_Non-HIV/Dengue/PNASU.110.9072.pdf:PDF}, groups = {public}, institution = {Oxford University Clinical Research Unit, District 5, Ho Chi Minh City, Vietnam.}, interhash = {37cf20c789e4a879520524b868fce48e}, intrahash = {95ded46dda9b4db0740bdb52259c9c97}, journal = {Proc Natl Acad Sci U S A}, keywords = {dengue virus transmission mosquito}, language = {eng}, medline-pst = {ppublish}, month = May, number = 22, pages = {9072--9077}, pii = {1303395110}, pmid = {23674683}, timestamp = {2013-06-08T02:11:42.000+0200}, title = {Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes.}, url = {http://dx.doi.org/10.1073/pnas.1303395110}, username = {aorchid}, volume = 110, year = 2013 }