%0 Journal Article %1 Schiefke.2005 %A Schiefke, I. %A Rogalski, C. %A Zabel-Langhennig, A. %A Witzigmann, H. %A Mössner, J. %A Hasenclever, Dirk %A Caca, K. %D 2005 %J Endoscopy %K IMISE-Publikationen %N 3 %P 217–222 %T Are endoscopic antireflux therapies cost-effective compared with laparoscopic fundoplication? %V 37 %X BACKGROUND AND STUDY AIMS A number of endoscopic antireflux therapies (EATs) have emerged as potential nonmedical treatment options for patients with gastroesophageal reflux disease (GERD). Concerns about clinical efficacy and costs have given rise to debate about their role in GERD management. The costs of laparoscopic fundoplication (LF) were compared with the costs of EAT when used in a sequential strategy that reserves the option of LF for EAT failure. METHODS A simple mathematical criterion of direct medical costs was applied. Published articles concerning EAT were reviewed to assess its effectiveness, durability and costs, in order to estimate the parameters of the model. The costs of EAT and LF were evaluated from the perspective of a German third-party payer. Only direct medical costs were considered. RESULTS Assuming that EAT has no impact on potential LF later on, the outcome of both strategies (LF, or EAT first with LF in case of failure of EAT) is identical and preference is a simple question of costs. The sequential strategy in nonmedical GERD treatment would be preferable if the long-term relief rate with EAT exceeds the ratio of the cost of EAT to the cost of LF. Long-term success rates of EAT do not exceed 0.65. At current prices EAT is clearly not cost-effective in Germany. CONCLUSION Our simple criterion indicates that EAT would only be cost-effective and beneficial in a sequential strategy if the costs of EAT were to be decreased to around 30 \% of current retail prices. However, long-term studies and randomized controlled trials are necessary to finally determine the role of EAT in GERD treatment, and the preference may change in either direction.

@article{Schiefke.2005, abstract = {BACKGROUND AND STUDY AIMS A number of endoscopic antireflux therapies (EATs) have emerged as potential nonmedical treatment options for patients with gastroesophageal reflux disease (GERD). Concerns about clinical efficacy and costs have given rise to debate about their role in GERD management. The costs of laparoscopic fundoplication (LF) were compared with the costs of EAT when used in a sequential strategy that reserves the option of LF for EAT failure. METHODS A simple mathematical criterion of direct medical costs was applied. Published articles concerning EAT were reviewed to assess its effectiveness, durability and costs, in order to estimate the parameters of the model. The costs of EAT and LF were evaluated from the perspective of a German third-party payer. Only direct medical costs were considered. RESULTS Assuming that EAT has no impact on potential LF later on, the outcome of both strategies (LF, or EAT first with LF in case of failure of EAT) is identical and preference is a simple question of costs. The sequential strategy in nonmedical GERD treatment would be preferable if the long-term relief rate with EAT exceeds the ratio of the cost of EAT to the cost of LF. Long-term success rates of EAT do not exceed 0.65. At current prices EAT is clearly not cost-effective in Germany. CONCLUSION Our simple criterion indicates that EAT would only be cost-effective and beneficial in a sequential strategy if the costs of EAT were to be decreased to around 30 \% of current retail prices. However, long-term studies and randomized controlled trials are necessary to finally determine the role of EAT in GERD treatment, and the preference may change in either direction.}, added-at = {2014-10-15T15:04:22.000+0200}, author = {Schiefke, I. and Rogalski, C. and Zabel-Langhennig, A. and Witzigmann, H. and Mössner, J. and Hasenclever, Dirk and Caca, K.}, biburl = {https://www.bibsonomy.org/bibtex/2d0c303305b53c82dd70f612522656568/drtester}, interhash = {38593b94123eda23d6aacab6a9869078}, intrahash = {d0c303305b53c82dd70f612522656568}, journal = {Endoscopy}, keywords = {IMISE-Publikationen}, number = 3, pages = {217–222}, timestamp = {2014-12-03T00:09:08.000+0100}, title = {Are endoscopic antireflux therapies cost-effective compared with laparoscopic fundoplication?}, volume = 37, year = 2005 }