%0 Journal Article %1 stock_autonomic_2010 %A Stock, Claire %A Teyssier, Georges %A Pichot, Vincent %A Goffaux, Philippe %A Barthelemy, Jean-Claude %A Patural, Hugues %D 2010 %J Autonomic Neuroscience: Basic & Clinical %K Adolescent Adult Age_Factors Autonomic_Nervous_System Baroreflex Female Heart_Rate Humans Infant Male Newborn Premature Respiratory_Syncytial_Virus_Infections Respiratory_Syncytial_Viruses Sleep Virus_Latency Young_Adult %N 1-2 %P 90--95 %R 10.1016/j.autneu.2010.03.012 %T Autonomic dysfunction with early respiratory syncytial virus-related infection %U http://www.ncbi.nlm.nih.gov/pubmed/20399711 %V 156 %X BACKGROUND Apparent life-threatening events (ALTE) and/or prolonged apnoea have been well-documented during respiratory syncytial virus (RSV) infection in infants less than 2 months of age but fundamental mechanisms remain unclear. The possibility of a central origin for the development of severe cardiac and respiratory events encouraged us, to explore the autonomic nervous system (ANS) profile of infected infants, since ANS activity may contribute to the constellation of symptoms observed during severe forms of RSV bronchiolitis. METHODS Eight infants (2 preterm and 6 full-term) less than 2 months of age and presenting with severe and apnoeic forms of RSV infection were evaluated using non-invasive electrophysiological monitoring obtained simultaneously for approximately 2 consecutive hours, including a quiet sleep period. Eight control subjects, paired for gestational and postnatal age, were also evaluated. ANS status was monitored using electrocardiogram recordings and quantified through a frequency-domain analysis of heart rate variability (HRV). This included sympathetic (VLF and LF) and parasympathetic (HF) indices as well as a measure of baroreflex sensitivity (BRS) obtained using non-invasive continuous arterial pressure. RESULTS Regardless of gestational and postnatal age, heart rate variability components (Ptot, VLF, LF, and HF) and baroreflex components (alpha LF, alpha HF and sBR) were found to be significantly lower in the RSV-infected group than in the control group (p\textless0.05). CONCLUSION RSV infection in neonates is associated with profound central autonomic dysfunction. The potentially fatal consequence stresses the importance of maintaining prolonged cardiopulmonary monitoring.

@article{stock_autonomic_2010, abstract = {{BACKGROUND} Apparent life-threatening events {(ALTE)} and/or prolonged apnoea have been well-documented during respiratory syncytial virus {(RSV)} infection in infants less than 2 months of age but fundamental mechanisms remain unclear. The possibility of a central origin for the development of severe cardiac and respiratory events encouraged us, to explore the autonomic nervous system {(ANS)} profile of infected infants, since {ANS} activity may contribute to the constellation of symptoms observed during severe forms of {RSV} bronchiolitis. {METHODS} Eight infants (2 preterm and 6 full-term) less than 2 months of age and presenting with severe and apnoeic forms of {RSV} infection were evaluated using non-invasive electrophysiological monitoring obtained simultaneously for approximately 2 consecutive hours, including a quiet sleep period. Eight control subjects, paired for gestational and postnatal age, were also evaluated. {ANS} status was monitored using electrocardiogram recordings and quantified through a frequency-domain analysis of heart rate variability {(HRV).} This included sympathetic {(VLF} and {LF)} and parasympathetic {(HF)} indices as well as a measure of baroreflex sensitivity {(BRS)} obtained using non-invasive continuous arterial pressure. {RESULTS} Regardless of gestational and postnatal age, heart rate variability components {(Ptot}, {VLF}, {LF}, and {HF)} and baroreflex components (alpha {LF}, alpha {HF} and {sBR)} were found to be significantly lower in the {RSV-infected} group than in the control group (p{\textless}0.05). {CONCLUSION} {RSV} infection in neonates is associated with profound central autonomic dysfunction. The potentially fatal consequence stresses the importance of maintaining prolonged cardiopulmonary monitoring.}, added-at = {2011-08-03T20:31:37.000+0200}, author = {Stock, Claire and Teyssier, Georges and Pichot, Vincent and Goffaux, Philippe and Barthelemy, {Jean-Claude} and Patural, Hugues}, biburl = {https://www.bibsonomy.org/bibtex/20c406da6146510373cca58e0695d1417/crc_chus}, doi = {10.1016/j.autneu.2010.03.012}, interhash = {3ba073a0aec637350bb886a50aa6dcfb}, intrahash = {0c406da6146510373cca58e0695d1417}, issn = {1872-7484}, journal = {Autonomic Neuroscience: Basic \& Clinical}, keywords = {Adolescent Adult Age_Factors Autonomic_Nervous_System Baroreflex Female Heart_Rate Humans Infant Male Newborn Premature Respiratory_Syncytial_Virus_Infections Respiratory_Syncytial_Viruses Sleep Virus_Latency Young_Adult}, month = aug, note = {{PMID:} 20399711}, number = {1-2}, pages = {90--95}, timestamp = {2011-08-03T20:35:33.000+0200}, title = {Autonomic dysfunction with early respiratory syncytial virus-related infection}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20399711}, volume = 156, year = 2010 }