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Inhibition of macrophage apoptosis by Neisseria meningitidis requires nitric oxide detoxification mechanisms

, , , , , , and . Infection and Immunity, 74 (1): 729--33 (January 2006)PMID: 16369030.
DOI: 74/1/729

Abstract

Host-driven macrophage apoptosis contributes to innate immunity during bacterial infection. Neisseria meningitidis inhibits apoptosis in a variety of cells, but its impact on macrophage apoptosis is unknown. We demonstrate that N. meningitidis prevents macrophage apoptosis via genes encoding nitric oxide detoxification and a porin, PorB.

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