%0 Journal Article %1 Goldbeter2012Systems %A Goldbeter, A. %A Gérard, C. %A Gonze, D. %A Leloup, J. C. %A Dupont, G. %D 2012 %J FEBS Letters %K circadian-rhythms systems-biology %N 18 %P 2955--2965 %R 10.1016/j.febslet.2012.07.041 %T Systems biology of cellular rhythms %U http://dx.doi.org/10.1016/j.febslet.2012.07.041 %V 586 %X ► Detailed survey of experimental and modeling approaches to cellular rhythms. ► Cellular rhythms in development : from cAMP oscillations to the segmentation clock. ► Frequency-encoded cellular rhythms: GnRH, Calcium, and cAMP pulses. ► The Cdk network driving the cell cycle behaves as a self-sustained oscillator. ► Coupled cellular rhythms: the cell cycle, Ca++ spiking, and the circadian clock. Rhythms abound in biological systems, particularly at the cellular level where they originate from the feedback loops present in regulatory networks. Cellular rhythms can be investigated both by experimental and modeling approaches, and thus represent a prototypic field of research for systems biology. They have also become a major topic in synthetic biology. We review advances in the study of cellular rhythms of biochemical rather than electrical origin by considering a variety of oscillatory processes such as Ca++ oscillations, circadian rhythms, the segmentation clock, oscillations in p53 and NF-κB, synthetic oscillators, and the oscillatory dynamics of cyclin-dependent kinases driving the cell cycle. Finally we discuss the coupling between cellular rhythms and their robustness with respect to molecular noise.

@article{Goldbeter2012Systems, abstract = {\^{a}–º Detailed survey of experimental and modeling approaches to cellular rhythms. \^{a}–º Cellular rhythms in development : from {cAMP} oscillations to the segmentation clock. \^{a}–º Frequency-encoded cellular rhythms: {GnRH}, Calcium, and {cAMP} pulses. \^{a}–º The Cdk network driving the cell cycle behaves as a self-sustained oscillator. \^{a}–º Coupled cellular rhythms: the cell cycle, Ca++ spiking, and the circadian clock. Rhythms abound in biological systems, particularly at the cellular level where they originate from the feedback loops present in regulatory networks. Cellular rhythms can be investigated both by experimental and modeling approaches, and thus represent a prototypic field of research for systems biology. They have also become a major topic in synthetic biology. We review advances in the study of cellular rhythms of biochemical rather than electrical origin by considering a variety of oscillatory processes such as Ca++ oscillations, circadian rhythms, the segmentation clock, oscillations in p53 and {NF}-{\^{I}ºB}, synthetic oscillators, and the oscillatory dynamics of cyclin-dependent kinases driving the cell cycle. Finally we discuss the coupling between cellular rhythms and their robustness with respect to molecular noise.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Goldbeter, A. and G\'{e}rard, C. and Gonze, D. and Leloup, J. C. and Dupont, G.}, biburl = {https://www.bibsonomy.org/bibtex/24e53bc268b22fbc55ae8b66f31d12733/karthikraman}, citeulike-article-id = {10985720}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.febslet.2012.07.041}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/22841722}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=22841722}, day = 25, doi = {10.1016/j.febslet.2012.07.041}, interhash = {5396555a0687502689d7a8ef222a77a1}, intrahash = {4e53bc268b22fbc55ae8b66f31d12733}, issn = {00145793}, journal = {FEBS Letters}, keywords = {circadian-rhythms systems-biology}, month = aug, number = 18, pages = {2955--2965}, pmid = {22841722}, posted-at = {2012-08-07 05:57:33}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Systems biology of cellular rhythms}, url = {http://dx.doi.org/10.1016/j.febslet.2012.07.041}, volume = 586, year = 2012 }