%0 Journal Article %1 schukin2004 %A Shchukin, Dmitry G. %A Patel, Amish A. %A Sukhorukov, Gleb B. %A Lvov, Yuri M. %D 2004 %J Journal of the American Chemical Society %K capsule dna %N 11 %P 3374-3375 %R 10.1021/ja036952x %T Nanoassembly of Biodegradable Microcapsules for DNA Encasing %U http://pubs.acs.org/doi/abs/10.1021/ja036952x %V 126 %X A new microcontainer for DNA delivery based on biocompatible polyβ-glucuronic acid-(1 → 3)-N-acetyl-β-galactosamine-6-sulfate-(1 → 4)(chondroitin sulfate)/poly(-l-arginine) microcapsules with 40 nm thick molecularly organized shell was proposed. DNA molecules were deposited as DNA/sperimidine complex on the surface of template 4 μm core particles followed by layer-by-layer nanoassembly of protective chondroitin sulfate/poly(-l-arginine) shell. After template core dissolution, DNA molecules were captured inside microcapsules retaining a natural double-helix structure. The developed DNA encapsulation approach can be employed for targeted delivery of plasmid DNA in living cells.

@article{schukin2004, abstract = { A new microcontainer for DNA delivery based on biocompatible poly[β-glucuronic acid-(1 → 3)-N-acetyl-β-galactosamine-6-sulfate-(1 → 4)](chondroitin sulfate)/poly(-l-arginine) microcapsules with 40 nm thick molecularly organized shell was proposed. DNA molecules were deposited as DNA/sperimidine complex on the surface of template 4 μm core particles followed by layer-by-layer nanoassembly of protective chondroitin sulfate/poly(-l-arginine) shell. After template core dissolution, DNA molecules were captured inside microcapsules retaining a natural double-helix structure. The developed DNA encapsulation approach can be employed for targeted delivery of plasmid DNA in living cells. }, added-at = {2011-06-04T01:26:18.000+0200}, author = {Shchukin, Dmitry G. and Patel, Amish A. and Sukhorukov, Gleb B. and Lvov, Yuri M.}, biburl = {https://www.bibsonomy.org/bibtex/2f35f6e494e9d2a4e4127d94959b80d7e/saghi}, description = {Nanoassembly of Biodegradable Microcapsules for DNA Encasing - Journal of the American Chemical Society (ACS Publications)}, doi = {10.1021/ja036952x}, eprint = {http://pubs.acs.org/doi/pdf/10.1021/ja036952x}, interhash = {1637674e6437155e03a5759543ed91e9}, intrahash = {f35f6e494e9d2a4e4127d94959b80d7e}, journal = {Journal of the American Chemical Society}, keywords = {capsule dna}, note = {PMID: 15025435}, number = 11, pages = {3374-3375}, timestamp = {2011-06-04T01:26:18.000+0200}, title = {Nanoassembly of Biodegradable Microcapsules for DNA Encasing}, url = {http://pubs.acs.org/doi/abs/10.1021/ja036952x}, volume = 126, year = 2004 }