Zusammenfassung
Rose Bengal@alpha-cyclodextrin (RB@alpha-CD) microparticles (mu Ps) were
prepared and the RB inclusion in alpha-CD was experimentally
demonstrated through infrared, UV-VIS absorption spectroscopy and cyclic
voltammetry. The RB inclusion in alpha-CD was theoretically investigated
using classical molecular mechanics calculations, the simulation results
showing that RB can be included in both the narrow and wide apertures of
the alpha-cyclodextrin ring with configurations exhibiting average binding energies of about 27 kcal mol(-1). The prepared RB@alpha-CD
microparticles were characterized through Scanning Electron Microscopy
(SEM) and it was demonstrated that they are highly efficient in the
photodynamic therapy against a Streptococcus mutans (the main bacteria
of cariogenic dental plaque) suspension, as a concentration of RB@alpha-CD mu Ps 10 times smaller than the usual concentration of pure
RB is still capable to produce significant antibacterial activity.
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