Article,
Clinical and Functional State of the Kidneys in Middle-Age Patients with Arterial Hypertension
CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (6): 919-925 (December 2023)
Abstract
Purpose of the study– assessment of the functional state of the kidneys and the formation of chronic kidney disease in middle-aged patients with arterial hypertension without associated diseases. Material and methods. 58 patients aged 38 to 60 years with a diagnosis of arterial hypertension were examined. A clinical diagnostic examination was carried out in the hospital: examination and history taking, biochemical blood test, general urine test, determination of glomerular filtration rate, monitoring of the clinical condition and tests during the hospital stay after 3 and 6 months. The study did not include patients with associated diseases or severe diseases of internal organs. Results and its discussion. In patients with arterial hypertension and without associated cardiovascular diseases, the main factors influencing the formation of renal dysfunction, manifested by hyposthenuria, albuminuria and proteinuria, are smoking, obesity, dyslipidemia and arterial hypertension. When arterial hypertension lasted more than 10 years, hypertensive nephropathy and chronic kidney disease were diagnosed in 67% of cases. Сonclusions. The results of the study confirm that smoking, obesity, dyslipidemia and arterial hypertension influence the formation of kidney dysfunction, manifested by albuminuria/proteinuria. The risk of developing hypertensive nephropathy with a duration of arterial hypertension of more than 10 years is 13 times higher than the risk of developing renal dysfunction with a duration of arterial hypertension of less than 5 years (RR=13.3, CI 95% 1.92–92.61;p<0.001). Nephroprotective antihypertensive therapy promotes reverse regression of albuminuria.
