%0 Journal Article %1 harrison_antigenic_2006 %A Harrison, Lee H %A Jolley, Keith A %A Shutt, Kathleen A %A Marsh, Jane W %A O'Leary, Mary %A Sanza, Laurie Thomson %A Maiden, Martin C J %D 2006 %J The Journal of Infectious Diseases %K Acid Amino Antigenic Antigens, Bacterial Bacterial, Data, Genes, Humans, Incidence, Infections, Membrane Meningococcal Molecular Mutation, Neisseria Outer Porins Proteins, Sequence Sequence, Substitution, Variation, meningitidis, %N 9 %P 1266--1274 %R 10.1086/501371 %T Antigenic shift and increased incidence of meningococcal disease %U http://www.ncbi.nlm.nih.gov/pubmed/16586364 %V 193 %X BACKGROUND: The incidence of serogroup C and Y meningococcal disease increased in the United States during the 1990s. The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease. METHODS: We characterized an increasing incidence of invasive serogroup C and Y meningococcal disease using population-based surveillance from 1992 through 2001. Isolates were characterized by multilocus sequence typing and antigen sequence typing of 3 outer membrane protein (OMP) genes: porA variable regions (VRs) 1 and 2, porB, and fetA VR. RESULTS: For both serogroups, OMP antigenic shifts were associated with increased incidence of meningococcal disease. For serogroup Y, antigenic shift occurred through amino acid substitutions at all 3 OMPs--PorA VR 1 and 2, PorB, and FetA VR. For serogroup C, antigenic shift involved amino acid substitutions at FetA VR and, in some cases, deletion of the porA gene. On the basis of deduced amino acid sequences, the antigenic changes likely occurred by horizontal gene transfer. CONCLUSIONS: Antigenic shifts were associated with increased incidence of serogroup C and serogroup Y meningococcal disease. For serogroup Y, the changes involved all OMP genes that were studied. Increases in the incidence of meningococcal disease may be caused, in part, by antigenic shift.

@article{harrison_antigenic_2006, abstract = {{BACKGROUND:} The incidence of serogroup C and Y meningococcal disease increased in the United States during the 1990s. The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease. {METHODS:} We characterized an increasing incidence of invasive serogroup C and Y meningococcal disease using population-based surveillance from 1992 through 2001. Isolates were characterized by multilocus sequence typing and antigen sequence typing of 3 outer membrane protein {(OMP)} genes: {porA} variable regions {(VRs)} 1 and 2, {porB,} and {fetA} {VR.} {RESULTS:} For both serogroups, {OMP} antigenic shifts were associated with increased incidence of meningococcal disease. For serogroup Y, antigenic shift occurred through amino acid substitutions at all 3 {OMPs--PorA} {VR} 1 and 2, {PorB,} and {FetA} {VR.} For serogroup C, antigenic shift involved amino acid substitutions at {FetA} {VR} and, in some cases, deletion of the {porA} gene. On the basis of deduced amino acid sequences, the antigenic changes likely occurred by horizontal gene transfer. {CONCLUSIONS:} Antigenic shifts were associated with increased incidence of serogroup C and serogroup Y meningococcal disease. For serogroup Y, the changes involved all {OMP} genes that were studied. Increases in the incidence of meningococcal disease may be caused, in part, by antigenic shift.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Harrison, Lee H and Jolley, Keith A and Shutt, Kathleen A and Marsh, Jane W and {O'Leary}, Mary and Sanza, Laurie Thomson and Maiden, Martin C J}, biburl = {https://www.bibsonomy.org/bibtex/2e6a07eb69877dad4c20e6bdd63ba49c5/jelias}, doi = {10.1086/501371}, interhash = {7b197e291fea3a72f03d39eca61b12da}, intrahash = {e6a07eb69877dad4c20e6bdd63ba49c5}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {Acid Amino Antigenic Antigens, Bacterial Bacterial, Data, Genes, Humans, Incidence, Infections, Membrane Meningococcal Molecular Mutation, Neisseria Outer Porins Proteins, Sequence Sequence, Substitution, Variation, meningitidis,}, month = may, note = {{PMID:} 16586364}, number = 9, pages = {1266--1274}, timestamp = {2011-03-11T10:06:13.000+0100}, title = {Antigenic shift and increased incidence of meningococcal disease}, url = {http://www.ncbi.nlm.nih.gov/pubmed/16586364}, volume = 193, year = 2006 }