Abstract
The wide prevalence of hepatobiliary pathology (GBP) (from 3 to 15 per 1000 examined), the steady increase in morbidity, disability and mortality determines the relevance of this problem. In the pathogenesis of diseases of the hepatobiliary system and its progression, violation of intrahepatic hemodynamics is of great importance, which may be associated with damage to the endothelial lining of hepatic sinusoids and endothelial dysfunction (ED). The processes of progression of liver damage, in particular, neoangiogenesis and fibrosis in the liver are also closely related to the functional viability of the endothelium. It is relevant to study the pathogenesis of liver damage in non-carious diseases of the hard tissues of teeth and to develop methods for assessing the severity of combined pathology.
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